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In unstressed wild populations, parasitic infections often go unnoticed and are perceived to represent a lesser threat to fish health. In contrast, platyhelminth parasitism of captive fish often results in decreased weight gain and increased mortality which often necessitates chemotherapeutic treatment. The presence of platyhelminth parasites in fish tissues is not only unappealing but in some cases also represents a threat to human health. In veterinary medicine, one of the most commonly used agents with anti\u2010flatworm activity is praziquantel; yet, no praziquantel products are labeled for use in fish in the United States. Veterinarians may use praziquantel preparations approved for other vertebrate species under the Animal Medicinal Drug Use Clarification Act (<jats:styled-content style=\"fixed-case\">AMDUCA<\/jats:styled-content>). However, such extra\u2010label use should be informed by scientific evidence including efficacy and tissue residue studies. Herein, we review studies testing the efficacy of praziquantel for treatment of platyhelminthes along with an assessment of routes of administration, pharmacokinetics, and toxicity information.<\/jats:p>","DOI":"10.1111\/jvp.12735","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T04:13:32Z","timestamp":1545020012000},"page":"139-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Use of praziquantel to control platyhelminth parasites of fish"],"prefix":"10.1111","volume":"42","author":[{"given":"Chris","family":"Bader","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology Iowa State University College of Veterinary Medicine  Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Starling","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Iowa State University College of Veterinary Medicine  Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology Iowa State University College of Veterinary Medicine  Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7538-1934","authenticated-orcid":false,"given":"Matthew T.","family":"Brewer","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology Iowa State University College of Veterinary Medicine  Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1179\/136485905X17407"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00382638"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2017.07.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-017-5703-8"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12640"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2015.10.137"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00578511"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.07.013"},{"issue":"4","key":"e_1_2_12_10_1","first-page":"846","article-title":"Therapeutic effect of subcurative dose praziquantel on Schistosoma mansoni infected mice and resistance to challenge infection after treatment","volume":"36","author":"Chaiworaporn R.","year":"2005","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"issue":"2","key":"e_1_2_12_11_1","first-page":"239","article-title":"Influence of parasitic infection on food intake","volume":"43","author":"Crompton D. 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