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This study was a prospective, blinded, randomized, negative control clinical trial in 65 healthy dogs presented for ovariohysterectomy. Anaesthesia was induced and maintained, for Group 1 (<jats:styled-content style=\"fixed-case\">TIVA<\/jats:styled-content>) dogs (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) with intravenous alfaxalone alone and for Group 2 dogs (<jats:italic>n<\/jats:italic>\u00a0=\u00a035) with thiopental followed by isoflurane in 100% oxygen inhalation. After ovariohysterectomy, quantitative measures of pain or nociception were recorded at 15\u00a0min intervals for 4\u00a0hr using three independent scoring systems, a composite measure pain scale (<jats:styled-content style=\"fixed-case\">CMPS<\/jats:styled-content>), von Frey threshold testing and measures of fentanyl rescue analgesia. The mean<jats:styled-content style=\"fixed-case\">CMPS<\/jats:styled-content>scores of Group 2 (<jats:styled-content style=\"fixed-case\">THIO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ISO<\/jats:styled-content>) dogs remained higher than Group 1 (<jats:styled-content style=\"fixed-case\">TIVA<\/jats:styled-content>) dogs from 15 to 135\u00a0min post\u2010surgery but this difference was not statistically significant. There were no significant differences between groups in the proportions of dogs requiring rescue fentanyl analgesia, the total fentanyl dose used or the time to first fentanyl dose. The Von Frey threshold testing was found to be unsuitable for measurement of pain in this experimental model. When administered as total intravenous anaesthesia, alfaxalone did not provide analgesia in the postoperative period.<\/jats:p>","DOI":"10.1111\/jvp.12740","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T09:50:53Z","timestamp":1548150653000},"page":"268-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A controlled randomized clinical trial to assess postoperative analgesia after thiopental\u2013isoflurane anaesthesia or total intravenous anaesthesia with alfaxalone in dogs"],"prefix":"10.1111","volume":"42","author":[{"given":"Paula M.","family":"Bennell","sequence":"first","affiliation":[{"name":"Melbourne Veterinary School University of Melbourne Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-903X","authenticated-orcid":false,"given":"Ted","family":"Whittem","sequence":"additional","affiliation":[{"name":"Melbourne Veterinary School University of Melbourne Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Tudor","sequence":"additional","affiliation":[{"name":"Melbourne Veterinary School University of Melbourne Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Anonymous. 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