{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:34:55Z","timestamp":1777624495005,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Macrolides are important antimicrobials frequently used in human and veterinary medicine in the treatment of pregnant women and pregnant livestock. They may be useful for the control of infectious ovine abortion, which has economic, animal health, and human health impacts. In this study, catheters were surgically placed in the fetal vasculature and amnion of pregnant ewes at 115 (\u00b12) days of gestation. Ewes were given a single dose of 2.5\u00a0mg\/kg tulathromycin subcutaneously, and drug concentrations were determined in fetal plasma, maternal plasma, and amniotic fluid at 4, 8, 12, 24, 36, 48, 72, 144, and 288\u00a0hr after drug administration. Pharmacokinetic parameters in maternal plasma were estimated using noncompartmental analysis and were similar to those previously reported in nonpregnant ewes. Tulathromycin was present in fetal plasma and amniotic fluid, indicating therapeutic potential for use against organisms in these compartments, though concentrations were lower than those in maternal plasma. Time\u2010course of drug concentrations in the fetus was quite different than that in the ewe, with plasma concentrations reaching a plateau at 4\u00a0hr and remaining at this concentration for the remainder of the sampling period (288\u00a0hr), raising questions about how tulathromycin may be transported into or metabolized and eliminated by the fetus.<\/jats:p>","DOI":"10.1111\/jvp.12744","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T04:39:01Z","timestamp":1547786341000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacokinetics of tulathromycin in fetal sheep and pregnant ewes"],"prefix":"10.1111","volume":"42","author":[{"given":"Evelyn E.","family":"MacKay","sequence":"first","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Texas A&amp;M University  College Station Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5291-3328","authenticated-orcid":false,"given":"Kevin E.","family":"Washburn","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Texas A&amp;M University  College Station Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley L.","family":"Padgett","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology Michael E. DeBakey Institute College of Veterinary Medicine and Biomedical Sciences Texas A&amp;M University  College Station Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0697-7149","authenticated-orcid":false,"given":"Virginia R.","family":"Fajt","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology Michael E. DeBakey Institute College of Veterinary Medicine and Biomedical Sciences Texas A&amp;M University  College Station Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Ping","family":"Lo","sequence":"additional","affiliation":[{"name":"Texas A&amp;M Veterinary Medical Diagnostic Laboratory  College Station Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis P.","family":"Mays","sequence":"additional","affiliation":[{"name":"Texas A&amp;M Veterinary Medical Diagnostic Laboratory  College Station Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6454-9770","authenticated-orcid":false,"given":"Shannon E.","family":"Washburn","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology Michael E. 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