{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:41:07Z","timestamp":1774690867923,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"American Association of Zoo Veterinarians Wild Animal Health Fund"},{"name":"Toronto Zoological Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was designed to investigate the pharmacokinetics of imidocarb, a carbanilide derivative, in white\u2010tailed deer (<jats:italic>Odocoileus virginianus<\/jats:italic>). The pharmacokinetic properties of a single intramuscular (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>) dose of imidocarb were determined in 10 deer. A single <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> injection of 3.0\u00a0mg\/kg imidocarb dipropionate was administered, and blood samples were collected prior to, and up to 48\u00a0hr after imidocarb administration. Plasma imidocarb concentrations were determined by high\u2010performance liquid chromatography with ultraviolet detection. The disposition of plasma imidocarb was best characterized by a two\u2010compartment open model. The mean\u00a0\u00b1\u00a0<jats:italic><jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content><\/jats:italic> maximal imidocarb concentration in deer was 880.78\u00a0\u00b1\u00a081.12\u00a0ng\/<jats:styled-content style=\"fixed-case\">ml<\/jats:styled-content> at 38.63\u00a0\u00b1\u00a05.30\u00a0min postinjection. The distribution phase had a half\u2010life (<jats:italic>t<\/jats:italic><jats:sub>1\/2<jats:italic>\u03b1<\/jats:italic><\/jats:sub>) of 25.90\u00a0\u00b1\u00a010.21\u00a0min, and plasma imidocarb concentration declined with a terminal elimination half\u2010life (<jats:italic>t<\/jats:italic><jats:sub>1\/2<jats:italic>\u03b2<\/jats:italic><\/jats:sub>) of 464.06\u00a0\u00b1\u00a0104.08\u00a0min (7.73\u00a0\u00b1\u00a01.73\u00a0hr). Apparent volume of distribution based on the terminal phase (<jats:italic>V<\/jats:italic><jats:sub>Z<\/jats:sub>\/<jats:italic>F<\/jats:italic>) was 9.20\u00a0\u00b1\u00a02.70\u00a0L\/kg, and apparent total body clearance (Cl\/<jats:italic>F<\/jats:italic>) was 15.97\u00a0\u00b1\u00a01.28\u00a0<jats:styled-content style=\"fixed-case\">ml<\/jats:styled-content>\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a0kg<jats:sup>\u22121<\/jats:sup>.<\/jats:p>","DOI":"10.1111\/jvp.12760","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T13:05:57Z","timestamp":1554123957000},"page":"33-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetics of imidocarb dipropionate in white\u2010tailed deer (<i>Odocoileus virginianus<\/i>) after single intramuscular administration"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7797-2217","authenticated-orcid":false,"given":"Ellie L.","family":"Milnes","sequence":"first","affiliation":[{"name":"Ontario Veterinary College University of Guelph  Guelph Ontario Canada"},{"name":"Toronto Zoo  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Delnatte","sequence":"additional","affiliation":[{"name":"Toronto Zoo  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Woodbury","sequence":"additional","affiliation":[{"name":"Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Hering","sequence":"additional","affiliation":[{"name":"Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Lee","sequence":"additional","affiliation":[{"name":"Western College of Veterinary Medicine University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Gu","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-201X","authenticated-orcid":false,"given":"Ronette","family":"Gehring","sequence":"additional","affiliation":[{"name":"Veterinary Pharmacotherapeutics and Pharmacy Division Faculty of Veterinary Medicine Institute of Risk Assessment Science Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Johnson","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02214695"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1638\/2008-0011.1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516402776180124"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(06)72320-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.4.818"},{"key":"e_1_2_8_7_1","unstructured":"CVMP(2003).Imidocarb (Extension to sheep). Summary report. EMEA\/MRL\/881\/03\u2010FINAL. Committee for Medicinal Products for Veterinary Use European Agency for the Evaluation of Medicinal Products. Retrieved fromhttps:\/\/www.ema.europa.eu\/documents\/mrl-report\/imidocarb-extension-sheep-summary-report-3-committee-veterinary-medicinal-products_en.pdf"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.223.1027"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-001-0576-1"},{"issue":"2","key":"e_1_2_8_10_1","first-page":"79","article-title":"Depletion and bioavailability of imidocarb residues in sheep and goat tissues","volume":"44","author":"Lai O.","year":"2002","journal-title":"Veterinary and Human Toxicology"},{"issue":"1","key":"e_1_2_8_11_1","first-page":"52","article-title":"Babesia odocoilei as a cause of mortality in captive cervids in Canada","volume":"59","author":"Mathieu A.","year":"2018","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7589\/2018-06-147"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(96)03705-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712799828355"},{"key":"e_1_2_8_15_1","first-page":"647","volume-title":"Fowler's zoo and wild animal medicine current therapy, volume 9","author":"Pastor A.","year":"2018"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2007.00872.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.01.048"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvp.12760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvp.12760","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T05:55:42Z","timestamp":1694152542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/jvp.12760"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12760","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2018-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}