{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:25:26Z","timestamp":1760171126955,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31702291","31872526"],"award-info":[{"award-number":["31702291","31872526"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Pasteurella multocida<\/jats:italic> is the causative agent of fowl cholera, and florfenicol (<jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content>) has potent antibacterial activity against <jats:italic>P.\u00a0multocida<\/jats:italic> and is widely used in the poultry industry. In this study, we established a <jats:italic>P.\u00a0multocida<\/jats:italic> infection model in ducks and studied the pharmacokinetics of <jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> in serum and lung tissues after oral administration of 30\u00a0mg\/kg bodyweight. The maximum concentrations reached (<jats:italic>C<\/jats:italic><jats:sub>max)<\/jats:sub> were lower in infected ducks (13.88\u00a0\u00b1\u00a02.70\u00a0\u03bcg\/ml) vs. healthy control animals (17.86\u00a0\u00b1\u00a01.57\u00a0\u03bcg\/ml). In contrast, the mean residence time (MRT: 2.35\u00a0\u00b1\u00a00.13 vs. 2.27\u00a0\u00b1\u00a00.18\u00a0hr) and elimination half\u2010life (<jats:italic>T<\/jats:italic><jats:sub>\u00bd\u03b2<\/jats:sub>: 1.63\u00a0\u00b1\u00a00.08 vs. 1.57\u00a0\u00b1\u00a00.12\u00a0hr) were similar for healthy and diseased animals, respectively. As a result, the area under the concentration curve for 0\u201312\u00a0hr (AUC<jats:sub>0\u201312\u00a0hr<\/jats:sub>) for <jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> in healthy ducks was significantly greater than that in infected ducks (49.47\u00a0\u00b1\u00a05.31 vs. 34.52\u00a0\u00b1\u00a08.29\u00a0\u03bcg\u00a0hr\/ml). The pharmacokinetic differences of <jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> in lung tissues between the two groups correlated with the serum pharmacokinetic differences. The <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> and <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u201312\u00a0hr<\/jats:sub> values of lung tissue in healthy ducks were higher than those in diseased ducks. The concentration of <jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> in lung tissues was approximately 1.2\u2010fold higher than that in serum both in infected and healthy ducks indicating that <jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> is effective in treating respiratory tract infections in ducks.<\/jats:p>","DOI":"10.1111\/jvp.12761","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T05:58:57Z","timestamp":1553579937000},"page":"355-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparative pharmacokinetics of florfenicol in healthy and <i>Pasteurella multocida<\/i>\u2010infected Gaoyou ducks"],"prefix":"10.1111","volume":"42","author":[{"given":"Weixuan","family":"Lan","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Xiao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu China"},{"name":"Jiangsu Co\u2010innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou Jiangsu China"},{"name":"Institutes of Agricultural Science and Technology Development Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjia","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijie","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyang","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biwen","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congcong","family":"Li","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Bian","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-9600","authenticated-orcid":false,"given":"Zhiqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu China"},{"name":"Jiangsu Co\u2010innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou Jiangsu China"},{"name":"Institutes of Agricultural Science and Technology Development Yangzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","first-page":"178","article-title":"Tissue concentrations and pharmacokinetics of florfenicol in broiler chickens","volume":"104","author":"Afifi N. 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