{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:42:24Z","timestamp":1790671344470,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pharmacokinetics (PK) and pharmacodynamics (PD) of marbofloxacin (MBF) were determined in six healthy female goats of age 1.00\u20131.25\u00a0years after repeated administration of MBF. The MBF was administered intramuscularly (IM) at 2\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup> for 5\u00a0days. Plasma concentrations of MBF were determined by high\u2010performance liquid chromatography, and PK parameters were obtained using noncompartmental analysis. The MBF concentrations peaked at 1\u00a0hr, and peak concentration (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>) was 1.760\u00a0\u00b5g\/ml on day 1 and 1.817\u00a0\u00b5g\/ml on day 5. Repeated dosing of MBF caused no significant change in PK parameters except area under curve (AUC) between day 1 (AUC<jats:sub>0\u2013\u221e<\/jats:sub>D1\u00a0=\u00a07.67\u00a0\u00b1\u00a00.719\u00a0\u00b5g\u00a0\u00d7\u00a0hr\/ml) and day 5 (AUC<jats:sub>0\u2010\u221e<\/jats:sub>D5\u00a0=\u00a08.70\u00a0\u00b1\u00a00.857\u00a0\u00b5g\u00a0\u00d7\u00a0hr\/ml). A slight difference in mean residence time between 1st and 5th day of administration and accumulation index (AI\u00a0=\u00a01.13\u00a0\u00b1\u00a00.017) suggested lack of drug accumulation following repeated IM administration up to 5\u00a0days. Minimum inhibitory concentration (MIC) demonstrated that <jats:italic>Escherichia coli<\/jats:italic> (MIC\u00a0=\u00a00.04\u00a0\u00b5g\/ml) and <jats:italic>Pasturella multocida<\/jats:italic> (MIC\u00a0=\u00a00.05\u00a0\u00b5g\/ml) were highly sensitive to MBF. Time\u2010kill kinetics demonstrated rapid and concentration\u2010dependent activity of MBF against these pathogens. PK\/PD integration of data for <jats:italic>E.\u00a0coli<\/jats:italic> and <jats:italic>P.\u00a0multocida,<\/jats:italic> using efficacy indices: <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>\/MIC and AUC<jats:sub>0\u201324hr<\/jats:sub>\/MIC, suggested that IM administration of MBF at a dose of 2\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup> is appropriate to treat infections caused by <jats:italic>E. coli<\/jats:italic>. However, a dose of 5\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup> is recommended to treat pneumonia caused by <jats:italic>P. multocida<\/jats:italic> in goats. The study indicated that MBF can be used repeatedly at dosage of 2\u00a0mg\/kg in goats without risk of drug accumulation up to 5\u00a0days.<\/jats:p>","DOI":"10.1111\/jvp.12776","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T05:03:51Z","timestamp":1558155831000},"page":"430-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacokinetic\u2013pharmacodynamic relationship of marbofloxacin for <i>Escherichia coli<\/i> and <i>Pasturella multocida<\/i> following repeated intramuscular administration in goats"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1459-6285","authenticated-orcid":false,"given":"Pallavi","family":"Bhardwaj","sequence":"first","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India"},{"name":"Department of Veterinary Pharmacology and Toxicology, Dr. G.C. Negi College of Veterinary and Animal Sciences CSK H.P. Agricultural University Palampur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3784-5982","authenticated-orcid":false,"given":"Pritam K.","family":"Sidhu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Kansas State University Manhattan Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simrat Pal Singh","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"M.B.","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyavan","family":"Rampal","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,17]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"19th Livestock Census(2012).Department of Animal Husbandry Dairying and Fisheries Ministry of Agriculture and Farmers Welfare Government of India. 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