{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:35:29Z","timestamp":1768638929901,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009587","name":"School of Veterinary Science, Shiraz University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Finding a medical treatment which can combat cell proliferation and relax smooth muscles in canine benign prostatic hyperplasia (BPH) appears to be imperative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to evaluate the oxidative stress and inflammatory proteins following the treatment of dogs induced for BPH with an anti\u2010proliferative agent called tadalafil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010five adult intact male dogs were randomly designated into five groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a05): Control group was not induced for BPH and not treated with tadalafil; dogs induced for BPH by testosterone enanthate and estradiol benzoate and treated with tadalafil (5\u00a0mg\/day P.O.); dogs which received tadalafil (5\u00a0mg\/day P.O.); dogs induced for BPH and treated with castration; and dogs induced for BPH. Oxidative stress factors (glutathione peroxidase [GPX], superoxide dismutase [SOD], catalase) and inflammatory proteins (haptoglobin, serum amyloid A [SAA], malondialdehyde [MDA]) were measured in the blood serum for four sequential weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Glutathione peroxidase and SOD serum levels declined in dogs in the BPH\u2010induced group compared to those in the control group. Those levels diminished in BPH\u2010induced castrated and tadalafil\u2010treated groups. The changes in the GPX and SOD serum concentrations were not significant between the BPH\u2010induced castrated group and BPH\u2010induced tadalafil\u2010treated group. Moreover, MDA concentration increased slightly in groups with BPH and groups which were castrated. Generally, however, there were no significant differences in the MDA serum concentrations between other groups. Haptoglobin and SAA concentrations increased in BPH\u2010castrated group. Also, the differences in haptoglobin and SAA were not significant between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tadalafil could not control oxidative stress and inflammatory mediators which happened during BPH in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jvp.12805","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T05:44:33Z","timestamp":1565761473000},"page":"665-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Changes in the oxidative stress factors and inflammatory proteins following the treatment of BPH\u2010induced dogs with an anti\u2010proliferative agent called tadalafil"],"prefix":"10.1111","volume":"42","author":[{"given":"Nooshin","family":"Dearakhshandeh","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine Shiraz University Shiraz Fars Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3136-2288","authenticated-orcid":false,"given":"Asghar","family":"Mogheiseh","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine Shiraz University Shiraz Fars Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Nazifi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine Shiraz University Shiraz Fars Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Saeed","family":"Ahrari Khafi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine Shiraz University Shiraz Fars Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Abbaszadeh Hasiri","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine Shiraz University Shiraz Fars Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Golchin\u2010Rad","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine Shiraz University Shiraz Fars Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"937","article-title":"Progesterone and cilostazol protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide","volume":"13","author":"Ahangarpour A.","year":"2014","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2012.11.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-014-3040-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(96)00000-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(02)00548-1"},{"key":"e_1_2_9_7_1","volume-title":"Small animal surgery (3th ed.)","author":"Fossum T. 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