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Multiple pathophysiological mechanisms are proposed, with the strongest evidence supporting aldosterone\u2010induced vasculopathy, exacerbation of oxidative stress and inflammation, and increased growth factor signalling promoting fibroblast proliferation and deranged extracellular matrix homeostasis. Further involvement of the MR is supported by extensive animal model experiments where MR antagonists (such as spironolactone and eplerenone) abrogate renal injury, including ischaemia\u2010induced damage. Additionally, clinical trials have shown MR antagonists to be beneficial in human chronic kidney disease (CKD) in terms of reducing proteinuria and cardiovascular events, though current studies have not evaluated primary end points which allow conclusions to made about whether MR antagonists reduce mortality or slow CKD progression. Although differences between human and feline CKD exist, feline CKD shares many characteristics with human disease including tubulointerstitial fibrosis. This review evaluates the evidence for the role of the MR in renal injury and summarizes the literature concerning aldosterone in feline CKD. MR antagonists may represent a promising therapeutic strategy in feline CKD.<\/jats:p>","DOI":"10.1111\/jvp.12848","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T05:49:00Z","timestamp":1583300940000},"page":"243-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1574-3910","authenticated-orcid":false,"given":"Sarah","family":"Spencer","sequence":"first","affiliation":[{"name":"Comparative Biomedical Sciences The Royal Veterinary College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Wheeler\u2010Jones","sequence":"additional","affiliation":[{"name":"Comparative Biomedical Sciences The Royal Veterinary College London 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