{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T16:22:21Z","timestamp":1783786941584,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"OYP","award":["2017-OYP-008"],"award-info":[{"award-number":["2017-OYP-008"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to determine the influences of supportive therapy (ST) on the pharmacokinetics (PK) of marbofloxacin in lipopolysaccharide (LPS)\u2010induced endotoxemic sheep. Furthermore, minimum inhibitory concentration (MIC) of marbofloxacin against <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Mannheimia haemolytica<\/jats:italic>, <jats:italic>Pasteurella multocida<\/jats:italic>, <jats:italic>Klebsiella pneumoniae<\/jats:italic>, <jats:italic>Salmonella<\/jats:italic> spp., and <jats:italic>Staphylococcus aureus<\/jats:italic> was determined. The study was performed using a three\u2010period cross PK design following a 15\u2010day washout period. In the first period, marbofloxacin (10\u00a0mg\/kg) was administered by an intravenous (IV) injection. In the second and third periods, marbofloxacin was co\u2010administered with ST (lactated ringer\u00a0+\u00a05% dextrose\u00a0+\u00a00.45% sodium chloride, IV, 20\u00a0ml\/kg, dexamethasone 0.5\u00a0mg\/kg, SC) and ST\u00a0+\u00a0LPS (<jats:italic>E.\u00a0coli<\/jats:italic> O55:B5, 10\u00a0\u00b5g\/kg), respectively. Plasma marbofloxacin concentration was measured using HPLC\u2010UV. Following IV administration of marbofloxacin alone, the <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jvp12849-math-0001.png\" xlink:title=\"urn:x-wiley:01407783:media:jvp12849:jvp12849-math-0001\"\/>, AUC<jats:sub>0\u2013\u221e<\/jats:sub>, Cl<jats:sub>T<\/jats:sub>, and <jats:italic>V<\/jats:italic><jats:sub>dss<\/jats:sub> were 2.87\u00a0hr, 34.73\u00a0hr\u00a0\u00d7\u00a0\u00b5g\/ml, 0.29\u00a0L\u00a0hr<jats:sup>\u22121<\/jats:sup>\u00a0kg<jats:sup>\u22121<\/jats:sup>, and 0.87\u00a0L\/kg, respectively. While no change was found in the MBX\u00a0+\u00a0ST group in terms of the PK parameters of marbofloxacin, it was determined that the Cl<jats:sub>T<\/jats:sub> of marbofloxacin decreased, AUC<jats:sub>0\u2013\u221e<\/jats:sub> increased, and <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jvp12849-math-0002.png\" xlink:title=\"urn:x-wiley:01407783:media:jvp12849:jvp12849-math-0002\"\/> and MRT prolonged in the MBX\u00a0+\u00a0ST\u00a0+\u00a0LPS group. MIC values of marbofloxacin were 0.031 to &gt;16\u00a0\u00b5g\/ml for <jats:italic>E.\u00a0coli<\/jats:italic>, 0.016 to &gt;16\u00a0\u00b5g\/ml for <jats:italic>M.\u00a0haemolytica<\/jats:italic>, 0.016\u20131\u00a0\u00b5g\/ml for <jats:italic>P.\u00a0multocida<\/jats:italic>, 0.016\u20130.25\u00a0\u00b5g\/ml for <jats:italic>K.\u00a0pneumoniae<\/jats:italic>, 0.031\u20130.063\u00a0\u00b5g\/ml for <jats:italic>Salmonella<\/jats:italic> spp., and 0.031\u20131\u00a0\u00b5g\/ml for <jats:italic>S.\u00a0aureus<\/jats:italic>. The study results show the necessity to make a dose adjustment of marbofloxacin following concomitant administration of ST in endotoxemic sheep. Also, the PK and pharmacodynamic effect of marbofloxacin needs to be determined in naturally infected septicemic sheep following concomitant administration of single and ST.<\/jats:p>","DOI":"10.1111\/jvp.12849","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T05:09:22Z","timestamp":1583384962000},"page":"288-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of supportive therapy on the pharmacokinetics of intravenous marbofloxacin in endotoxemic sheep"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1151-1861","authenticated-orcid":false,"given":"Devran","family":"Coskun","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine University of Siirt Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-2510","authenticated-orcid":false,"given":"Orhan","family":"Corum","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine University of Kastamonu Kastamonu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enver","family":"Yazar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine University of Selcuk Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.15312\/EurasianJVetSci.2016422396"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2019.03.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2017.12.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.16-0641"},{"key":"e_1_2_8_6_1","unstructured":"Anonymous(2019). 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