{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:41:40Z","timestamp":1747186900237,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001655","name":"Grayson-Jockey Club Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005350","name":"American Association of Equine Practitioners Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although controversial, due to its reported effectiveness in attenuating bleeding associated with exercise\u2010induced pulmonary hemorrhage (EIPH), furosemide is currently a permitted race day medication in most North American racing jurisdictions. The objective of this study was to assess the efficacy of furosemide in reducing the presence and severity of EIPH when administered 24\u00a0hr prior to strenuous treadmill exercise. Eight exercised Thoroughbred horses received saline or 250\u00a0mg of furosemide either 4 or 24\u00a0hr prior to high\u2010speed treadmill exercise in a balanced 3\u2010way cross\u2010over design. Blood samples were collected for determination of furosemide, lactate, hemoglobin, blood gas, and electrolyte concentrations. Heart rate and pulmonary arterial pressure were measured throughout the run and endoscopic examination and bronchoalveolar lavage (BAL) performed. Horses were assigned an EIPH score and the number of red blood cells in BAL fluid determined. Although not significantly different, endoscopic EIPH scores were lower in the 4\u2010hr versus the 24\u2010hr and saline groups. RBC counts were not significantly different between the treatment groups. Pulmonary arterial pressures were significantly increased at higher speeds; however, there were no significant differences between dose groups when controlling for speed. A small sample size and unknown bleeding history warrant a larger\u2010scale study.<\/jats:p>","DOI":"10.1111\/jvp.12881","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T06:28:18Z","timestamp":1591079298000},"page":"565-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physiologic effects of furosemide in combination with water restriction when administered at 4 and 24 hours prior to high\u2010intensity treadmill training"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8676-4970","authenticated-orcid":false,"given":"Heather K.","family":"Knych","sequence":"first","affiliation":[{"name":"K.L. Maddy Equine Analytical Pharmacology Laboratory School of Veterinary Medicine University of California, Davis Davis CA USA"},{"name":"Department of Veterinary Molecular Biosciences School of Veterinary Medicine University of California, Davis Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. David","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology School of Veterinary Medicine University of California, Davis Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Vale","sequence":"additional","affiliation":[{"name":"Private Practitioner San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip H.","family":"Kass","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction School of Veterinary Medicine University of California, Davis Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene P.","family":"Steffey","sequence":"additional","affiliation":[{"name":"Department of Surgical &amp; Radiological Sciences School of Veterinary Medicine University of California, Davis Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Surgical &amp; Radiological Sciences School of Veterinary Medicine University of California, Davis Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick M.","family":"Arthur","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California, Davis Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15574"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(94)90029-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.5.1584"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2006.tb05595.x"},{"key":"e_1_2_8_6_1","first-page":"476","article-title":"Exercise\u2010induced pulmonary hemorrhage","volume":"18","author":"Erickson H.","year":"1994","journal-title":"Equine Veterinary Journal. 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