{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:33:20Z","timestamp":1791401600522,"version":"4.3.3"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T00:00:00Z","timestamp":1594512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mark Derrick Canine Research Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This multi\u2010institutional study was designed to determine the clinical pharmacokinetics of fluconazole and outcomes in client\u2010owned dogs (<jats:italic>n<\/jats:italic>\u00a0=\u00a037) and cats (<jats:italic>n<\/jats:italic>\u00a0=\u00a035) with fungal disease. Fluconazole serum concentrations were measured. Pharmacokinetic analysis was limited to animals at steady state (\u226572\u00a0hr of treatment). The mean (range) body weight in 31 dogs was 25.6 (2.8\u201358.2) kg and in 31 cats was 3.9 (2.4\u20136.1) kg included in pharmacokinetic analyses. The dose, average steady\u2010state serum concentrations (C<jats:sub>SS<\/jats:sub>), and oral clearance in dogs were 14.2 (4.5\u201321.3) mg\/kg\/d, 26.8 (3.8\u201361.5) \u00b5g\/mL, and 0.63\u00a0ml\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a0kg<jats:sup>\u22121<\/jats:sup>, respectively, and in cats were 18.6 (8.2\u201340.0) mg\/kg\/d, 32.1 (1.9\u2013103.5) \u00b5g\/mL, and 0.61\u00a0ml\u00a0min<jats:sup>\u22121<\/jats:sup>\u00a0kg<jats:sup>\u22121<\/jats:sup>, respectively. Random inter\u2010animal pharmacokinetic variability was high in both species. Two dogs had near twofold increases in serum fluconazole when generic formulations were changed, suggesting lack of bioequivalence. Median C<jats:sub>SS<\/jats:sub> for dogs and cats achieving clinical remission was 19.4 and 35.8\u00a0\u00b5g\/ml, respectively. Starting oral doses of 10\u00a0mg\/kg q12h in dogs and 50\u2013100\u00a0mg total daily dose in cats are recommended to achieve median C<jats:sub>SS<\/jats:sub> associated with clinical remission. Due to the large pharmacokinetic variability, individualized dose adjustments based on C<jats:sub>SS<\/jats:sub> (therapeutic drug monitoring) and treatment failure should be considered.<\/jats:p>","DOI":"10.1111\/jvp.12888","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T05:54:25Z","timestamp":1594619665000},"page":"547-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical pharmacokinetics and outcomes of oral fluconazole therapy in dogs and cats with naturally occurring fungal disease"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0215-3284","authenticated-orcid":false,"given":"Kate","family":"KuKanich","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Kansas State University Manhattan KS 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