{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:36:23Z","timestamp":1790710583406,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objectives of this study were (a) to establish a population pharmacokinetic model and (b) to investigate the clinical and physiological effects of a single bolus dose of propofol in common marmosets. In Study 1, pharmacokinetic analysis was performed in six marmosets under sevoflurane anaesthesia. 8\u00a0mg\/kg of propofol was administrated at a rate of 4\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0min<jats:sup>\u22121<\/jats:sup>. Blood samples were collected 2, 5, 15, 30, 60, 90, 120 or 180\u00a0min after starting propofol administration. Plasma concentration was measured, and population pharmacokinetic modelling was performed. A two\u2010compartment model was selected as the final model. The population pharmacokinetic parameters were as follows: V<jats:sub>1<\/jats:sub>\u00a0=\u00a01.14 L, V<jats:sub>2<\/jats:sub>\u00a0=\u00a077.6 L, CL<jats:sub>1<\/jats:sub>\u00a0=\u00a00.00182 L\/min, CL<jats:sub>2<\/jats:sub>\u00a0=\u00a00.0461 L\/min. In Study 2, clinical and physiological parameters were assessed and recorded every 2\u00a0min after 12\u00a0mg\/kg of propofol was administrated at a rate of 4\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0min<jats:sup>\u22121<\/jats:sup>. Immobilization was sustained for 5\u00a0min following propofol administration without apparent bradycardia. While combination of propofol and sevoflurane caused apnoea in Study 1, apnoea was not observed following single administration of propofol in Study 2. These data provide bases for further investigation on intravenous anaesthesia using propofol in common marmosets.<\/jats:p>","DOI":"10.1111\/jvp.12905","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:46:49Z","timestamp":1599076009000},"page":"18-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacokinetics and effects on clinical and physiological parameters following a single bolus dose of propofol in common marmosets (<i>Callithrix jacchus<\/i>)"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-1538","authenticated-orcid":false,"given":"Kanako","family":"Muta","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Surgery Graduate School of Agricultural and Life Sciences the University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6502-655X","authenticated-orcid":false,"given":"Takako","family":"Miyabe\u2010Nishiwaki","sequence":"additional","affiliation":[{"name":"Center for Human Evolution Modeling Research Primate Research Institute Kyoto University  Inuyama Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Masui","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Showa University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Yajima","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Defense Medical College Hospital  Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery Graduate School of Agricultural and Life Sciences the University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Center for Human Evolution Modeling Research Primate Research Institute Kyoto University  Inuyama Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery Graduate School of Agricultural and Life Sciences the University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","first-page":"339","article-title":"Aspects of common marmoset basic biology and life history important for biomedical research","volume":"53","author":"Abbott D. H.","year":"2003","journal-title":"Comparative Medicine"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep143"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2005.03.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.5.659"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198806000-00004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2017.06.009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-9-113"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2009.08.022"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2012.02.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498259209046648"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000219597.16143.4D"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/65.6.760"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2012.06.009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.27.123"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.06.021"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1994.tb03576.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200111000-00026"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12553"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2005.00251.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/86.4.523"},{"issue":"4","key":"e_1_2_8_22_1","first-page":"383","article-title":"Marmoset models commonly used in biomedical research","volume":"53","author":"Mansfield K.","year":"2003","journal-title":"Comparative Medicine"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181b799c1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2010.00564.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2012.01404.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2987.2001.00052.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2012.07.002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2010.12.003"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000175214.38450.91"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10950"},{"issue":"5","key":"e_1_2_8_31_1","first-page":"H1509","article-title":"Measurement of blood pressure and heart rate by telemetry in conscious unrestrained marmosets","volume":"264","author":"Schnell C.","year":"1993","journal-title":"American Journal of Physiology"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01070999"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200002000-00021"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.4.356"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01143186"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199901000-00014"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/80.4.488"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12905","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvp.12905","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T11:12:02Z","timestamp":1693739522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,2]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/jvp.12905"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12905","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,2]]},"assertion":[{"value":"2020-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}