{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:41:46Z","timestamp":1747186906020,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the pharmacokinetic profile of co\u2010administration of tulathromycin with rifampicin. Healthy male goats were allocated to three groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) as Group A (single dose 2.5\u00a0mg\/kg tulathromycin s.c.), B (10\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup> rifampicin p.o. daily for 7\u00a0days and single dose 2.5\u00a0mg\/kg tulathromycin s.c. on 8th day),\u00a0and\u00a0C (10\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup> rifampicin p.o. daily for 21\u00a0days and single dose 2.5\u00a0mg\/kg tulathromycin s.c. on 8th day). Blood samples were collected from jugular veins. Plasma samples were analyzed for tulathromycin by liquid chromatography\u2013mass spectrometry (LC\u2010MS\/MS). Peak plasma concentration (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>) values of tulathromycin were 1,390\u00a0\u00b1\u00a0173, 958\u00a0\u00b1\u00a0106, and 807\u00a0\u00b1\u00a0116\u00a0ng\/ml in groups A, B, and C, respectively. <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> value of group A was greater than other groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Mean residence time based on time zero to last sample time (MRT<jats:sub>last<\/jats:sub>) values were 52\u00a0\u00b1\u00a01, 56\u00a0\u00b1\u00a04 and 66\u00a0\u00b1\u00a04\u00a0hr in A, B, and C groups, respectively whereas mean residence time based on time zero extrapolated to infinity (MRT<jats:sub>INF_obs<\/jats:sub>) values were 69\u00a0\u00b1\u00a04, 85\u00a0\u00b1\u00a05, and 86\u00a0\u00b1\u00a04\u00a0hr, respectively. MRT<jats:sub>last<\/jats:sub> and MRT<jats:sub>INF_obs<\/jats:sub> values were greater in B and C groups than group A (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). These findings suggest that rifampicin administration may change several pharmacokinetic parameters of tulathromycin in goats.<\/jats:p>","DOI":"10.1111\/jvp.12928","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T03:07:58Z","timestamp":1604632078000},"page":"374-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of rifampicin on plasma pharmacokinetics of tulathromycin in goats"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2811-3579","authenticated-orcid":false,"given":"Hande Sultan","family":"\u015eahiner","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Ayd\u0131n Adnan Menderes University Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4032-3950","authenticated-orcid":false,"given":"Cavit","family":"Kum","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine Ayd\u0131n Adnan Menderes University Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2012.07.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/rvsc.1998.0244"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.8.1279"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1081\/DMR\u2010200.033.432"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20100711\u20105\u20103"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2011.10.025"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102885.2010.01261.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102885.2011.01300.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2007013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.7.2633\u20102637.2000"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh487"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2478\/bvip\u20102013\u20100035"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0351624"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552\u20104604.1998.tb05785.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.05.016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088\u2010200342090\u201000003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.115822"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102125.2000.00295.x"},{"issue":"1","key":"e_1_2_9_20_1","first-page":"60","article-title":"Pharmacokinetics and lung tissue concentrations of tulathromycin, a new triamilide antibiotic, in cattle","volume":"5","author":"Nowakowski M. 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