{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:41:52Z","timestamp":1747186912816,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:00:00Z","timestamp":1619222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["109 O 862"],"award-info":[{"award-number":["109 O 862"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sheep and goats are sharing different helminth parasites including <jats:italic>Haemonchus contortus<\/jats:italic>. Control of these helminths is based mainly on the use of anthelmintics. However, in goats, the application of anthelmintics is often carried out mainly at dosages determined for sheep without knowing the real effects and metabolism features. One of the several anthelmintic classes used against these parasites is (pro) benzimidazoles which are still widely in use in small ruminants in many countries. The objective of this study was to determine (i) the correlation between plasma and tissue or gastrointestinal content dispositions of ricobendazole (RBZ) in goats and (ii) the in vivo exposure of ricobendazole by <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>contortus<\/jats:italic>. Ten goats were experimentally infected with 10,000 larvae of <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>contortus<\/jats:italic>. Four weeks of post\u2010infection, the animals received RBZ subcutaneously at 5\u00a0mg\/kg body weight. Two goats were sacrificed per time at 1, 2, 4, 6 and 12\u00a0h after drug administration and, blood, bile, urine, liver, lung, muscle and kidney gastrointestinal tissues\/fluids were collected. Adult <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>contortus<\/jats:italic> were collected from abomasum, and all samples were analysed by HPLC system. Ricobendazole (RBZ) and its sulphone metabolite were extensively excreted by urine and distributed to all tissues and digestive tract, mainly into the abomasum fluid. RBZ concentration in the lung and ABZSO<jats:sub>2<\/jats:sub> in the kidney were relatively higher than those of other tissues, respectively. The parent drug and its metabolite were recovered in both male and female <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>contortus<\/jats:italic>. This study indicates that in goats the plasma concentration profiles of RBZ are strongly correlated with those achieved in different target tissues or fluids, which in turn, reflect the amount of drug taken up by parasites.<\/jats:p>","DOI":"10.1111\/jvp.12974","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T08:54:02Z","timestamp":1619254442000},"page":"799-807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>In vivo<\/i> exposure of Albendazole sulphoxide by <i>Haemonchus<\/i><i>contortus<\/i> and correlation between plasma and target tissue or gastrointestinal content dispositions in goats"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4912-7307","authenticated-orcid":false,"given":"Cengiz","family":"Gokbulut","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology Faculty of Medicine Balikesir University  Balikesir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veli Y.","family":"Cirak","sequence":"additional","affiliation":[{"name":"Department of Parasitology Faculty of Veterinary Medicine Bursa Uludag University  Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleyman","family":"Aypak","sequence":"additional","affiliation":[{"name":"Department of Parasitology Faculty of Veterinary Medicine University of Adnan Menderes  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdi","family":"Avci","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Medicine University of Adnan Menderes  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selim","family":"Sekkin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine University of Adnan Menderes  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2811-3579","authenticated-orcid":false,"given":"Hande S.","family":"Yalinkilinc","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Veterinary Medicine University of Adnan Menderes  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buket","family":"Boga","sequence":"additional","affiliation":[{"name":"Department of Parasitology Faculty of Veterinary Medicine University of Adnan Menderes  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erol","family":"Ayaz","sequence":"additional","affiliation":[{"name":"Department of Parasitology Faculty of Medicine Abant Izzet Baysal University  Bolu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,24]]},"reference":[{"volume-title":"Guidelines for the Euthanasia of Animals: 2020 Edition","year":"2020","author":"A.V.M.A.","key":"e_1_2_11_2_1"},{"key":"e_1_2_11_3_1","first-page":"77","article-title":"Anthelmintic efficacy of Ricobendazole injectable against helminthosis in sheep","volume":"2","author":"Abramova E.","year":"2014","journal-title":"Rossi\u012dski\u012d Parazitologicheski\u012d Zhurnal"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0442-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(00)00320-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.1999.00194.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1987.tb00106.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1645\/GE-3212RN"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(90)90231-R"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12438"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006496122684"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.146.12.350"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.246"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2001.00320.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498259109039463"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5288(91)90095-6"},{"key":"e_1_2_11_17_1","first-page":"994","article-title":"Physiological peculiarities of the ruminant relevant to drug distribution","volume":"26","author":"Dobson A.","year":"1967","journal-title":"Federation Proceedings"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00008581"},{"key":"e_1_2_11_19_1","first-page":"37","article-title":"Pharmacokinetics behaviour of ricobendazole in calves and sheep after its intravenous administration","volume":"156","author":"Formentini E. 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