{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:48:11Z","timestamp":1788781691289,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Incidence of<jats:italic>Bordetella pertussis<\/jats:italic>, the causative agent of whooping cough, is rising in some global human populations despite high vaccination rates, and significant research is underway to address the issue. Baboons are an established model for pertussis research, but like many mammals, they can be naturally infected with<jats:italic>Bordetella bronchiseptica<\/jats:italic>. Because<jats:italic>B<\/jats:italic>.\u00a0<jats:italic>bronchiseptica<\/jats:italic>interferes with<jats:italic>B<\/jats:italic>.\u00a0<jats:italic>pertussis<\/jats:italic>research, it must be excluded from baboons under consideration for enrollment in pertussis studies. In addition to research\u2010related concerns,<jats:italic>B<\/jats:italic>.\u00a0<jats:italic>bronchiseptica<\/jats:italic>can sometimes cause clinical disease in baboons and other nonhuman primates. This study examined the use of antibiotics to clear<jats:italic>B<\/jats:italic>.\u00a0<jats:italic>bronchiseptica<\/jats:italic>in naturally infected baboons. Thirty\u2010five juvenile baboons were divided into five treatment groups: oral sulfamethoxazole\/trimethoprim (TMS), nebulized gentamicin (gentamicin), combination (TMS\u00a0+\u00a0gentamicin) in positive animals, combination (TMS\u00a0+\u00a0gentamicin) as a prophylactic in exposed animals and no treatment (control). Combination of oral TMS and nebulized gentamicin given to positive animals was most effective, producing long\u2010term clearance in 11 out of 12 treated animals. To avoid unnecessary use of antibiotics, our primary management strategy is screening and separating to allow natural clearance and limiting exposure to non\u2010infected animals, but this study investigates an antibiotic regimen that could be used in special circumstances.<\/jats:p>","DOI":"10.1111\/jvp.12975","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T06:12:21Z","timestamp":1620540741000},"page":"836-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of oral, nebulized and combination antibiotic treatment of<i>Bordetella<\/i><i>bronchiseptica<\/i>in baboons (<i>Papio<\/i>spp.)"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2403-9415","authenticated-orcid":false,"given":"Elizabeth A.","family":"Clemmons","sequence":"first","affiliation":[{"name":"Southwest National Primate Research Center Texas Biomedical Research Institute San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Chavez","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center Texas Biomedical Research Institute San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Condel","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center Texas Biomedical Research Institute San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"John W.","family":"Dutton","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center Texas Biomedical Research Institute San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Price","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center Texas Biomedical Research Institute San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lanford","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center Texas Biomedical Research Institute San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Nonhuman Primates in Biomedical Research Volume 2: Diseases Second Edition","author":"Abee C.","year":"2012"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02360.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367783781062334"},{"key":"e_1_2_12_5_1","first-page":"1082","article-title":"Aerosol, parenteral, and oral antibiotic treatment of Bordetella\u2010bronchiseptica infections in dogs","volume":"170","author":"Bemis D. 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