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Subjects were randomized to receive IV and OS gabapentin in a cross\u2010over design, with at least 14\u00a0days of wash\u2010out period between the two rounds of drug administrations. Blood samples were obtained before gabapentin administration and at various times up to 24\u00a0h, and harvested plasma was stored at \u221280\u00b0C until analysis. Concentration of gabapentin was quantified using a previously validated liquid chromatography\/tandem mass spectrometry method, and compartment models were fitted to time\u2010concentration data using non\u2010linear mixed effect (population) analysis. A two\u2010compartment model best fitted the data following IV administration. Typical values for volume of the central compartment and clearance and calculated volume of distribution at steady\u2010state and terminal half\u2010life were 170\u00a0ml\/kg, 1.2\u00a0ml\/(kg*min), and 594\u00a0ml\/kg and 360\u00a0min, respectively. For the oral route, absorption half\u2010life, estimated maximal plasma concentration and time to reach maximal plasma concentration were 58\u00a0min, 9155\u00a0ng\/ml, and 194\u00a0min, respectively. Estimated oral bioavailability was 47%. Short\u2010lived sedation (approximately 15\u00a0min) with sternal or lateral recumbency after IV administration was observed in all subjects without adverse clinical effects. Simulation based on the results of this study suggests that a first oral gabapentin dose of 15\u00a0mg\/kg and subsequent doses of 8.5\u00a0mg\/kg every 8\u00a0h would achieve and maintain plasma concentrations between 5 and 8\u00a0\u03bcg\/ml in pigs.<\/jats:p>","DOI":"10.1111\/jvp.12977","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T10:49:05Z","timestamp":1620816545000},"page":"776-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetics of oral and compounded intravenous gabapentin in Duroc swine (<i>Sus<\/i><i>Scrofa<\/i>)"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8344-8569","authenticated-orcid":false,"given":"Chiara E.","family":"Hampton","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Science School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Queiroz\u2010Williams","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Science School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montana J.","family":"Oubre","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Martin","sequence":"additional","affiliation":[{"name":"Parkville Animal Hospital Parkville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea T.","family":"Gisclair","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0894-0991","authenticated-orcid":false,"given":"Bruno H.","family":"Pypendop","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California Davis Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15313"},{"key":"e_1_2_11_3_1","unstructured":"Anon. 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