{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:43:31Z","timestamp":1791593011872,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Grapiprant is the pioneer member of the novel piprant class, a potent and specific antagonist of the prostaglandin E2 receptor 4. It has been approved in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs at the dose regimen of 2\u00a0mg\/kg once a day by the FDA and EMA (for pain only) in 2016 and 2018, respectively. The aim of this narrative review was to report the analytical methods, pharmacokinetics, pharmacodynamics and safety of grapiprant in several animal species using the best available published scientific evidence. In conclusion, most of the analytical methods proposed for grapiprant detection are simple, reliable, sensitive and validated. The pharmacokinetics show discrepancies between animal species. The therapeutic efficacy seems more suited to chronic rather than acute pain.<\/jats:p>","DOI":"10.1111\/jvp.12983","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T11:50:58Z","timestamp":1622461858000},"page":"679-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Grapiprant: A snapshot of the current knowledge"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-4563","authenticated-orcid":false,"given":"Irene","family":"Sartini","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine University of Sassari Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-4703","authenticated-orcid":false,"given":"Mario","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Pisa Pisa Italy"},{"name":"PhD School Department of Veterinary Medicine University of Sassari Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"NADA 141\u2010455 GALLIPRANT","author":"Anonymous","year":"2016"},{"key":"e_1_2_12_3_1","volume-title":"Galliprant prescribing information","author":"Anonymous","year":"2016"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3844\/ajavsp.2018.45.50"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.028"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12348"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.10.106"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.80.11.1001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090\u20106980(01)00129\u20100"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2010.00647.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.134510"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2020.04.006"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.2460\/ajvr.1997.58.06.626","article-title":"Kinetic gait analysis assessment of meloxicam efficacy in a sodium urate\u2010induced synovitis model in dogs","volume":"58","author":"Cross A. R.","year":"1997","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010019\u20102116\u20101"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.11.004"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12380"},{"key":"e_1_2_12_17_1","first-page":"296","article-title":"Clinical efficacy and tolerance of meloxicam in dogs with chronic osteoarthritis","volume":"41","author":"Doig P. A.","year":"2000","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02311085"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161-1459.1000e103"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3844\/ajavsp.2015.53.56"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.11.005"},{"key":"e_1_2_12_22_1","first-page":"61","article-title":"Tolerance and pharmacokinetics of Galliprant\u2122 administered orally to Mdr1\u2010deficient collies. Session 18: Advances in companion animal medicine","volume":"41","author":"Heit M. C.","year":"2018","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2008.08.001"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700491"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.1170"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.07.008"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3844\/ajavsp.2013.89.97"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.13"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2378"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2231"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2016.1241727"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12414"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.105569"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215528"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195\u20105616(08)70016\u20100"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221\u2010009\u20101814\u20105"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12349"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.122010"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103940(95)11839\u2010O"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.76.10.853"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13948"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.77.7.688"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12306"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2009.10.005"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.12.006"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011408200"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.11.005"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.05.028"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102885.2004.00605.x"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003517"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.007195"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvp.12983","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.12983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T21:52:53Z","timestamp":1725141173000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.12983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/jvp.12983"],"URL":"https:\/\/doi.org\/10.1111\/jvp.12983","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,31]]},"assertion":[{"value":"2021-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}