{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:01:37Z","timestamp":1780563697629,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T00:00:00Z","timestamp":1643500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to determine the pharmacokinetic parameters of oclacitinib maleate as a top dress given to adult horses. Six adult horses with a mean weight of 528\u00a0kg were administered a single dose of 0.5\u00a0mg\/kg oclacitinib maleate. Blood was collected prior to drug administration and at 15\u00a0min, 30\u00a0min, 45\u00a0min, 1, 2, 4, 6, 8, 12, 24, 48, and 72\u00a0h after treatment. Oclacitinib maleate plasma concentrations were measured by liquid chromatography\/mass spectrometry. Pharmacokinetic parameters were found best to fit a one\u2010compartment model. Mean <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> was 486\u00a0ng\/ml (range 423\u2013549\u00a0ng\/ml), and <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub> was estimated to be 1.7\u00a0h (range 0.3\u20133.1\u00a0h). The estimated <jats:italic>T<\/jats:italic><jats:sub>1\/2<\/jats:sub> was 7.5\u20138\u00a0h.<\/jats:p>","DOI":"10.1111\/jvp.13043","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T04:58:36Z","timestamp":1643605116000},"page":"320-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetics of a single dose of oclacitinib maleate as\u00a0a\u00a0top dress in adult horses"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2572-5628","authenticated-orcid":false,"given":"Laszlo","family":"Hunyadi","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine Texas Tech University  Amarillo Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palika","family":"Datta","sequence":"additional","affiliation":[{"name":"Health Sciences Center Infant Risk Center Texas Tech University  Amarillo Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Rewers\u2010Felkins","sequence":"additional","affiliation":[{"name":"Health Sciences Center Infant Risk Center Texas Tech University  Amarillo Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7949-4266","authenticated-orcid":false,"given":"Emily","family":"Sundman","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Texas Tech University  Amarillo Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hale","sequence":"additional","affiliation":[{"name":"Health Sciences Center Infant Risk Center Texas Tech University  Amarillo Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0697-7149","authenticated-orcid":false,"given":"Virginia","family":"Fajt","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine &amp; Biomedical Sciences Texas A &amp; M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4046-7583","authenticated-orcid":false,"given":"Sarah","family":"Wagner","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Texas Tech University  Amarillo Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,30]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Apoquel Freedom of Information Summary","author":"Apoquel Freedom of Information Summary","year":"2013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20103306.1978.tb02271.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20103306.1990.tb04258.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20103306.1987.tb01389.x"},{"key":"e_1_2_10_6_1","volume-title":"Paper presented at the ACVIM Forum 2020, Virtual","author":"Collard W.","year":"2020"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12088"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12101"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12720"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12218"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20103164.2011.01001.x"},{"key":"e_1_2_10_12_1","volume-title":"Paper presented at the ACVIM Forum 2020, Virtual","author":"Visser M.","year":"2020"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.13043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvp.13043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.13043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:29:38Z","timestamp":1692718178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.13043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,30]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/jvp.13043"],"URL":"https:\/\/doi.org\/10.1111\/jvp.13043","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,30]]},"assertion":[{"value":"2021-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}