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One\u2010hundred fifteen (115) cats were randomized to a single topical dose of placebo solution, low\u2010TBS dosage (1.91\u20132.07\u2009mg\/kg) or high\u2010TBS dosage (4.27\u20134.88\u2009mg\/kg) prior to surgical reproductive sterilization in conjunction with forelimb onychectomy. The low\u2010 and high\u2010TBS doses were applied 2\u20134 and 1\u20132\u2009hours prior to surgery. Interactive pain assessments and physiological variables were quantified through 96\u00a0hours post\u2010anesthetic recovery and rescue analgesia was administered any time that analgesia was considered inadequate. Cats requiring rescue analgesia were considered treatment failures. The estimated overall treatment success rates from generalized linear mixed effects model analysis were 0.10 (95% CI: [0.02\u20130.36]), 0.56 (95% CI: [0.25\u20130.83]), 0.71 (95% CI: [0.38\u20130.91]) in the placebo\u2010, low\u2010, and high\u2010TBS dose groups, respectively. Success rates for both TBS treatment groups were superior to placebo. Adverse events were infrequent in all treatment groups although the postoperative body temperatures over the duration of the study were on average 0.31 (95% CI: [0.08\u20130.55]) and 0.30 (95% CI: [0.05\u20130.53]) \u00b0C higher in low\u2010 and high\u2010TBS dose cats, respectively, compared to placebo. It is concluded that both the low\u2010 and high\u2010TBS dosages were safe and effective. The high\u2010TBS dosage resulted in a greater proportion of treatment successes over 96\u00a0h, had a more acceptable preoperative application time of 1\u20132\u2009h prior to surgery, and was therefore selected for further study.<\/jats:p>","DOI":"10.1111\/jvp.13059","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T12:51:09Z","timestamp":1657025469000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multicentered masked placebo\u2010controlled phase 2 clinical study of an extended duration transdermal buprenorphine solution for postoperative pain in cats"],"prefix":"10.1111","volume":"45","author":[{"given":"Terrence P.","family":"Clark","sequence":"first","affiliation":[{"name":"Nexcyon Pharmaceuticals, Inc.  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