{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:17:36Z","timestamp":1789168656835,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012895","name":"Zoetis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Oclacitinib maleate (Apoquel\u00ae, Zoetis Inc.) is commonly used around the world for the control\/treatment of pruritus associated with allergic dermatitis and the control\/treatment of atopic dermatitis in dogs at least 12\u2009months of age. A new flavored chewable formulation of oclacitinib has been developed where more than 90% of doses offered to dogs were freely accepted when tested in clinical trials. The objective of this study was to determine whether the new chewable formulation of oclacitinib has a similar onset of anti\u2010pruritic activity as the original oclacitinib film\u2010coated tablets (FCT). Twenty\u2010one laboratory beagle dogs were randomized to treatment and received placebo, 0.4\u20130.6\u00a0mg\/kg oclacitinib FCT or 0.4\u20130.6\u00a0mg\/kg flavored chewable oclacitinib tablet (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a07\/group). Efficacy was measured by assessing reduction in pruritus 1\u20133\u00a0h post\u2010administration of treatments. Pruritus was induced by injecting canine IL\u201031, intravenously (2.5\u00a0\u03bcg\/kg), approximately 15\u2009min prior to the pruritus observation window. Results from this study demonstrated both oclacitinib FCT and the flavored chewable oclacitinib tablet significantly reduced IL\u201031\u2010induced pruritus within 1\u20133\u00a0h post\u2010dosing compared to placebo (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.0069 and .0113, respectively), suggesting the new formulation of oclacitinib chewable tablets works as quickly to reduce pruritus in dogs as the oclacitinib FCT.\n                  <\/jats:p>","DOI":"10.1111\/jvp.13065","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T03:41:58Z","timestamp":1652931718000},"page":"380-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Speed of onset of a new chewable formulation of oclacitinib maleate (Apoquel\u00ae) in a canine model of\n                    <scp>IL<\/scp>\n                    \u201031\u2010induced pruritus"],"prefix":"10.1111","volume":"45","author":[{"given":"Timothy","family":"Fleck","sequence":"first","affiliation":[{"name":"Veterinary Medicine Research &amp; Development Zoetis, Inc.  Kalamazoo Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Norris","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Research &amp; Development Zoetis, Inc.  Kalamazoo Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie","family":"King","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Research &amp; Development Zoetis, Inc.  Kalamazoo Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Lesman","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Research &amp; Development Zoetis, Inc.  Kalamazoo Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4972-5825","authenticated-orcid":false,"given":"Andrea J.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Research &amp; Development Zoetis, Inc.  Kalamazoo Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojvm.2018.88011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12087"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12047"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12088"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12166"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12280"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01098.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0514-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.02.012"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-022-03210-x"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.13065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvp.13065","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.13065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T06:11:56Z","timestamp":1692771116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.13065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,19]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/jvp.13065"],"URL":"https:\/\/doi.org\/10.1111\/jvp.13065","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,19]]},"assertion":[{"value":"2022-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}