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Blood samples were collected at assigned times up to 168\u2009h. DNX in the harvested crocodile plasma was extracted using liquid\u2013liquid extraction and analyzed using a validated high\u2010performance liquid chromatography method equipped with fluorescence detection. The pharmacokinetic analysis was performed using a non\u2010compartmental approach. DNX in plasma was quantifiable from 5\u00a0min to 168\u2009h after i.m. administration at the two dosages in freshwater crocodiles. The area under the curve (AUC) and maximum concentration (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>) values increased in a dose\u2010dependent fashion. Long elimination half\u2010life (48.18 and 67.29\u2009h) and low clearance (0.024 and 0.020\u2009ml\/g\u2009h) were obtained in the high\u2010 and low\u2010dose groups, respectively. According to the pharmacokinetic\u2010pharmacodynamic surrogate (AUC<jats:sub>0\u201324h<\/jats:sub>\/MIC &gt;\u2009125), i.m. single administration of DNX at a dosage of 6\u00a0mg\/kg b.w. is predicted to have antibacterial success for disease caused by bacteria with MIC &lt;\u20090.04\u2009\u03bcg\/ml in the freshwater crocodile, <jats:italic>C. siamensis.<\/jats:italic><\/jats:p>","DOI":"10.1111\/jvp.13072","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T07:56:25Z","timestamp":1652860585000},"page":"352-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacokinetics of danofloxacin in freshwater crocodiles (<i>Crocodylus siamensis<\/i>) after intramuscular injection"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5249-903X","authenticated-orcid":false,"given":"Saranya","family":"Poapolathep","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Medicine Kasetsart University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narumol","family":"Klangkaew","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Medicine Kasetsart University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Wongwaipairoj","sequence":"additional","affiliation":[{"name":"Wongveerakit Crocodile Farm  Kanchanaburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narongsak","family":"Chaiyabutr","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Science Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-4703","authenticated-orcid":false,"given":"Mario","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Pisa Via Livornese (latomonte)  San Piero a Grado Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amnart","family":"Poapolathep","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Medicine Kasetsart University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2013.01.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1996.tb00001.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2018.1530458"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.18\u20100609"},{"key":"e_1_2_10_6_1","first-page":"265","volume-title":"Antibiotics in laboratory medicine","author":"Craig A. 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