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Radiocarpal synovitis was induced in six healthy adult horses with the IA injection of LPS (0.5\u00a0ng\/joint) on two occasions in a randomized cross\u2010over design. Treatments (IA buprenorphine (IAB) at 5\u00a0\u03bcg\/kg plus intravenous saline; and intravenous buprenorphine (IVB) at 5\u00a0\u03bcg\/kg plus IA saline) were administered 4\u00a0h following LPS injection. Concentrations of buprenorphine were assessed in plasma and synovial fluid (SF) at 0.5, 2, 6, 12, and 24\u2009h after administration. Pharmacokinetic parameters after IVB and IAB in plasma and synovial fluid were calculated using a nonlinear mixed effects model. IAB was detectable in SF of all horses at 24\u2009h [median concentration of 6.2 (3.46\u201322.6) ng\/mL]. IAB resulted in a median plasma concentration of 0.59 (0.42\u20131.68) ng\/mL at 0.5\u00a0h and was detectable in all subjects for up to 6 h and in two horses for up to 12 h. IVB resulted in SF concentrations detected up to 6 h in all horses [median concentration of 0.12 (0.07\u20130.82) ng\/mL]. Results suggest that IA buprenorphine remains present in the inflamed joint for at least 24 h and systemic absorption occurs.<\/jats:p>","DOI":"10.1111\/jvp.13119","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T11:40:14Z","timestamp":1677152414000},"page":"229-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacokinetics of intra\u2010articular buprenorphine in horses with lipopolysaccharide\u2010induced synovitis"],"prefix":"10.1111","volume":"46","author":[{"given":"Gabriel","family":"Castro\u2010Cuellar","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-7576","authenticated-orcid":false,"given":"Jeannette","family":"Cremer","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Queiroz\u2010Williams","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8676-4970","authenticated-orcid":false,"given":"Heather K.","family":"Knych","sequence":"additional","affiliation":[{"name":"KL Maddy Equine Analytical Pharmacology Lab, School of Veterinary Medicine University of California, Davis Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta S.","family":"Leise","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.6.992"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/508186"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.3.246"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453678208992196"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.2.163"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12269"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_33_19"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2011.01284.x"},{"issue":"11","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.2460\/ajvr.1998.59.11.1476","article-title":"Hepatic blood flow in horses during the recuperative period from maximal exercise","volume":"59","author":"Dyke T. 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