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The objective of this study was to determine the pharmacokinetics of oral trazodone (T) alone, or in combination with gabapentin (G) in healthy cats. Cats (<jats:italic>n<\/jats:italic>\u2009=\u20096) were randomly allocated to receive T (3\u2009mg\/kg) intravenously (IV), T (5\u2009mg\/kg) orally (PO), or T (5\u2009mg\/kg) and G (10\u2009mg\/kg) PO with a 1\u2010week washout period between treatments. Heart rate, respiratory rate, indirect blood pressure, and level of sedation were assessed, and venous blood samples were collected serially over 24\u2009h. Analysis of plasma trazodone concentration was performed using liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS). Oral T administration resulted in a bioavailability of 54.9(7\u201396)%, and 17.2(11\u201325)% when administered with G. <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub> 0.17 (0.17\u20130.5) and 0.17 (0.17\u20130.75) h; <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> 1.67\u2009\u00b1\u20090.91 and 1.22\u2009\u00b1\u20090.54\u2009\u03bcg\/mL, AUC 5.23 (2.0\u201318.76) and 2.37 (1.17\u20137.80) h*\u03bcg\/mL; T<jats:sub>1\/2<\/jats:sub> 5.12\u2009\u00b1\u20092.56 and 4.71\u2009\u00b1\u20091.07\u2009h; for T and TG, respectively. Sedation was significant when compared to baseline in all groups from 20 or 45\u2009min to 8\u2009h indicating some lag between peak plasma concentration and sedative effects. Physiological variables remained within normal limits. This study concludes that oral trazodone is rapidly absorbed in healthy cats. Addition of gabapentin did not result in more profound sedation, showing no clinical advantage of combining these drugs in this study population.<\/jats:p>","DOI":"10.1111\/jvp.13384","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T17:34:22Z","timestamp":1682444062000},"page":"300-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacokinetic, sedative, and physiological effects of oral compounded formulations of trazodone alone or in combination with gabapentin in male cats"],"prefix":"10.1111","volume":"46","author":[{"given":"Laura E.","family":"Tucker","sequence":"first","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7565-1674","authenticated-orcid":false,"given":"Andrea","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8356-0104","authenticated-orcid":false,"given":"Alexander","family":"Valverde","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shauna","family":"Blois","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Uccello","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Monteith","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-5075","authenticated-orcid":false,"given":"Jennifer M.","family":"Reinhart","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, College of Veterinary Medicine University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Keating","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, College of Veterinary Medicine University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15313"},{"key":"e_1_2_11_3_1","first-page":"54","article-title":"Preparing a trazodone HCL suspension","volume":"15","author":"Allen L. 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