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Despite this, there is a paucity of data on safe and effective analgesia agents in pigs. Grapiprant is an EP4 antagonist that blocks the action of the pro\u2010inflammatory prostanoid, PGE<jats:sub>2<\/jats:sub>. It has shown efficacy in attenuating pain associated with ovariohysterectomy and OA in dogs. However, there are no data regarding grapiprant in pigs. Therefore, the pharmacokinetic profile of orally administered grapiprant to juvenile pigs (<jats:italic>Sus scrofa domestica<\/jats:italic>) was evaluated in this study. Seven juvenile pigs received 12\u2009mg\/kg grapiprant orally. Blood was collected from an indwelling jugular catheter using the push\u2013pull method at set timepoints up to 48\u2009hours. Sample analysis was performed with high\u2010performance liquid chromatography. Mean grapiprant plasma concentration was 164.3\u2009\u00b1\u2009104.7\u2009ng\/mL which occurred at 0.8\u2009\u00b1\u20090.3\u2009h. This study demonstrated that grapiprant concentrations consistent with analgesia in dogs were reached at this dosage in pigs. Further studies are needed to evaluate the efficacy of grapiprant in pigs.<\/jats:p>","DOI":"10.1111\/jvp.13402","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T12:27:41Z","timestamp":1690374461000},"page":"269-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacokinetics of a single oral dose of grapiprant in juvenile pigs (<i>Sus scrofa domestica<\/i>)"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-7492","authenticated-orcid":false,"given":"Stephanie","family":"Kleine","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine University of Tennessee  Knoxville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara E.","family":"Hampton","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, 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