{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:01:05Z","timestamp":1788184865390,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007404","name":"Suomen El\u00e4inl\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007404","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010126","name":"Juliana von Wendtin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010126","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019806","name":"Walter Ehrstr\u00f6min S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Meloxicam is routinely used for pain alleviation in pre\u2010ruminant calves during husbandry procedures. The pharmacokinetics of a single dose (0.5\u2009mg\/kg) of meloxicam was investigated after intravenous (IV), subcutaneous (SC), and oral (PO) administration in 30 pre\u2010ruminant calves. Each group included 10 calves. Oral meloxicam was administered at least 1\u2009h after feeding. Plasma samples were collected for up to 168\u2009h, and the meloxicam concentration was analysed with liquid chromatography and mass spectrometry, followed by a noncompartmental pharmacokinetic analysis. The maximum meloxicam concentrations in plasma were 1.91\u2009\u00b1\u20090.27\u2009\u03bcg\/mL and 1.77\u2009\u00b1\u20090.16\u2009\u03bcg\/mL after SC and PO routes, respectively. The time of maximum concentration was 7.6\u2009\u00b1\u20092.8\u2009h after SC and 10.0\u2009\u00b1\u20095.7\u2009h after PO administration. The approximate bioavailability of meloxicam was 97% for SC and PO routes. The elimination half\u2010lives were 79.2\u2009\u00b1\u200912.4, 84.6\u2009\u00b1\u200924.8, and 84.8\u2009\u00b1\u200922.3\u2009h after IV, SC, and PO routes, respectively. The results suggest that the therapeutic meloxicam concentrations in plasma that are required for pain relief in other species, such as horses, may be maintained for several days following a single dose (0.5\u2009mg\/kg) administered IV, SC, or PO in calves.<\/jats:p>","DOI":"10.1111\/jvp.13412","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T08:24:10Z","timestamp":1698481450000},"page":"143-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetics of meloxicam in pre\u2010ruminant calves after intravenous, oral, and subcutaneous administration"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6517-7591","authenticated-orcid":false,"given":"Annemari","family":"Jokela","sequence":"first","affiliation":[{"name":"Department of Production Animal Medicine, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"},{"name":"Research Centre for Animal Welfare, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Nyrhil\u00e4","sequence":"additional","affiliation":[{"name":"Department of Production Animal Medicine, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"},{"name":"Research Centre for Animal Welfare, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-5912","authenticated-orcid":false,"given":"Magdy","family":"Adam","sequence":"additional","affiliation":[{"name":"Research Centre for Animal Welfare, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"},{"name":"Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"},{"name":"Pharmacology Department, Faculty of Veterinary Medicine Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4975-5060","authenticated-orcid":false,"given":"Kati","family":"Salla","sequence":"additional","affiliation":[{"name":"Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-003X","authenticated-orcid":false,"given":"Marja","family":"Raekallio","sequence":"additional","affiliation":[{"name":"Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8143-2664","authenticated-orcid":false,"given":"Riikka","family":"Aho","sequence":"additional","affiliation":[{"name":"Department of Production Animal Medicine, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"},{"name":"Research Centre for Animal Welfare, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8130-3959","authenticated-orcid":false,"given":"Marianna","family":"Norring","sequence":"additional","affiliation":[{"name":"Department of Production Animal Medicine, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"},{"name":"Research Centre for Animal Welfare, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2011-4596","authenticated-orcid":false,"given":"Ann\u2010Helena","family":"Hokkanen","sequence":"additional","affiliation":[{"name":"Department of Production Animal Medicine, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"},{"name":"Research Centre for Animal Welfare, Faculty of Veterinary Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-011-0077-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2016-10949"},{"key":"e_1_2_11_4_1","first-page":"E1","article-title":"Pharmacokinetics of intravenous and oral meloxicam in ruminant calves","volume":"10","author":"Coetzee J. 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