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Six swine (<jats:italic>Sus scrofa domesticus<\/jats:italic>) of 6\u2009weeks old were administered NaGHB at a dose of 500\u2009mg\/kg intravenously (IV) and 500 and 750\u2009mg\/kg orally (PO) in a triple cross\u2010over design. Repeated blood sampling was performed to allow pharmacokinetic analysis of GHB. Whole blood concentration at time point 0 after IV administration was 1727.21\u2009\u00b1\u2009280.73\u2009\u03bcg\/mL, with a volume of distribution of 339.45\u2009\u00b1\u200951.41\u2009mL\/kg and clearance of 164.94\u2009\u00b1\u200947.05\u2009mL\/(kg\u2009h). The mean peak plasma concentrations after PO administration were 326.57\u2009\u00b1\u200936.70 and 488.01\u2009\u00b1\u2009154.62\u2009\u03bcg\/mL for 500\u2009mg\/kg and 750\u2009mg\/kg, respectively. These were recorded at 1.42\u2009\u00b1\u20090.72 and 1.58\u2009\u00b1\u20090.58\u2009h after PO dose for GHB 500\u2009mg\/kg and 750\u2009mg\/kg, respectively. The elimination half\u2010life for IV and PO 500\u2009mg\/kg and PO 750\u2009mg\/kg dose was respectively 1.33\u2009\u00b1\u20090.30, 1.16\u2009\u00b1\u20090.31 and 1.11\u2009\u00b1\u20090.33\u2009h. The bioavailability (<jats:italic>F<\/jats:italic>) for PO administration was 45%. No clinical adverse effects were observed after PO administration. Deep sleep was seen in one animal after IV administration, other animals showed head pressing and ataxia.<\/jats:p>","DOI":"10.1111\/jvp.13418","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T22:35:18Z","timestamp":1700606118000},"page":"95-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacokinetics of gamma\u2010hydroxybutyric acid in 6\u2010week\u2010old swine (<i>Sus scrofa domesticus<\/i>) after intravenous and oral administration"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0886-399X","authenticated-orcid":false,"given":"Charlotte","family":"Cuypers","sequence":"first","affiliation":[{"name":"Department of Large Animal Surgery, Anaesthesia and Orthopaedics, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-4176","authenticated-orcid":false,"given":"Mathias","family":"Devreese","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katleen","family":"Van Uytfanghe","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Stove","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7105-6517","authenticated-orcid":false,"given":"Stijn","family":"Schauvliege","sequence":"additional","affiliation":[{"name":"Department of Large Animal Surgery, Anaesthesia and Orthopaedics, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1369.065"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000943"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224747"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00099.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270002239707"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90982-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1994.1028"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666141210215423"},{"key":"e_1_2_11_10_1","first-page":"743","article-title":"Sodium oxybate in the treatment of alcohol withdrawal syndrome: A randomized double\u2010blind comparative study versus oxazepam. 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