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A total of 48 healthy crossbred, castrated male pigs (Landrace\u2010Yorkshire) weighing 23\u2009\u00b1\u20094.3\u2009kg were included in this trial. They were randomly assigned to six groups as follows: two groups for the experimental prototype 1 of doxycycline hyclate administering it ad\u00a0libitum (Fad\u2010lib) or as forced bolus (Fbolus); two groups for the experimental prototype 2 of doxycycline hyclate as for the former groups (FCad\u2010lib and FCbolus), and two control groups receiving the same dose of doxycycline hyclate, but of a commercial premix, also as previously explained (Cbolus and Cad\u2010lib). Statistical analysis of the mean pharmacokinetic values was carried out with Kruskal\u2013Wallis and Dunn's tests. The relative bioavailability (Fr) of the best prototype, when administered ad\u00a0libitum (FCad\u2010lib), was five times larger than the reference group (Cadlib). These results allow the proposal that the referred differences achieved in the presented prototypes can mark a notable clinical difference, particularly in pathogens with some resistance.<\/jats:p>","DOI":"10.1111\/jvp.13419","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T15:00:54Z","timestamp":1701183654000},"page":"107-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacokinetics of doxycycline hyclate in pigs with a new feed premix formulation"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5424-0557","authenticated-orcid":false,"given":"M\u00f3nica","family":"Zerme\u00f1o\u2010Acosta","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Aut\u00f3noma de M\u00e9xico  M\u00e9xico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8802-5274","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Sumano","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Aut\u00f3noma de M\u00e9xico  M\u00e9xico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3527-0807","authenticated-orcid":false,"given":"Jorge Luna\u2010del","family":"Villar","sequence":"additional","affiliation":[{"name":"Departamento de Cirug\u00eda, Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Aut\u00f3noma de M\u00e9xico  M\u00e9xico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-5656","authenticated-orcid":false,"given":"Maria Josefa","family":"Bernad","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  M\u00e9xico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-0388","authenticated-orcid":false,"given":"Lilia","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Aut\u00f3noma de M\u00e9xico  M\u00e9xico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016208703380"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079459408418976"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)00261-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.2000.00235.x"},{"key":"e_1_2_11_6_1","unstructured":"Borge C. 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