{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:37:06Z","timestamp":1777102626844,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study is to determine the pharmacokinetic change after intravenous administration of meloxicam at doses of 0.5, 1 and 2\u2009mg\/kg to sheep. The study was carried out on six Akkaraman sheep. Meloxicam was administered intravenously to each sheep at 0.5, 1, and 2\u2009mg\/kg doses in a longitudinal pharmacokinetic design with a 15\u2010day washout period. Plasma concentrations of meloxicam were determined using the high performance liquid chromatography\u2010ultraviolet, and pharmacokinetic parameters were evaluated by non\u2010compartmental analysis. Meloxicam was detected up to 48\u2009h in the 0.5\u2009mg\/kg dose and up to 96\u2009h in the 1 and 2\u2009mg\/kg doses. As the dose increased from 0.5 to 2\u2009mg\/kg, terminal elimination half\u2010life, and dose normalized area under the concentration versus time curve increased and total clearance decreased. Compared to the 1\u2009mg\/kg dose, it was determined that <jats:italic>V<\/jats:italic><jats:sub>dss<\/jats:sub> decreased and <jats:italic>C<\/jats:italic><jats:sub>0.083h<\/jats:sub> increased in the 2\u2009mg\/kg dose. Meloxicam provided the therapeutic concentration of &gt;0.39\u2009\u03bcg\/mL reported in other species for 12, 48 and 96\u2009h at 0.5, 1 and 2\u2009mg\/kg doses, respectively. These results show that meloxicam exhibits non\u2010linear pharmacokinetics and will achieve unpredictable plasma concentrations when administered IV for a rapid effect at dose of \u22651\u2009mg\/kg in sheep.<\/jats:p>","DOI":"10.1111\/jvp.13422","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T19:49:24Z","timestamp":1701373764000},"page":"202-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2506-3855","authenticated-orcid":false,"given":"Huseyin","family":"Gungor","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Sivas Cumhuriyet University  Sivas Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-2510","authenticated-orcid":false,"given":"Orhan","family":"Corum","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Hatay Mustafa Kemal University  Antakya Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-991X","authenticated-orcid":false,"given":"Duygu","family":"Durna\u00a0Corum","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Hatay Mustafa Kemal University  Antakya Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-4264","authenticated-orcid":false,"given":"Alper Serhat","family":"Kumru","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Sivas Cumhuriyet University  Sivas Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6495-5488","authenticated-orcid":false,"given":"G\u00f6khan","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Sivas Cumhuriyet University  Sivas Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1151-1861","authenticated-orcid":false,"given":"Devran","family":"Coskun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Siirt University  Siirt Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-9647","authenticated-orcid":false,"given":"Alparslan","family":"Coskun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Veterinary Medicine Sivas Cumhuriyet University  Sivas Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8674-4873","authenticated-orcid":false,"given":"Kamil","family":"Uney","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Selcuk University  Konya Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Anonymous. 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