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Twelve cats were randomly allocated to one subcutaneous treatment group: meloxicam (0.2\u2009mg\/kg) or robenacoxib (2\u2009mg\/kg) at admission (MA, RA), at induction (MI, RI) and robenacoxib at the end of surgery (RE). All cats received the same anaesthesia protocol. Plasma renin activity (PRA), plasma creatinine, drug concentrations and serum thromboxane (TxB<jats:sub>2<\/jats:sub>) were measured sequentially. Anaesthesia significantly increased PRA, as activity at end of the surgery was higher than 2\u2009h later (mean\u2009\u00b1\u2009SD: 26.6\u2009\u00b1\u20092.8 versus 10.0\u2009\u00b1\u20093.9\u2009ng\/mL\/h). PRA remained higher at 2\u2009h post\u2010surgery in admission groups compared to induction groups (<jats:italic>p<\/jats:italic>\u2009=\u2009.01). Serum TxB<jats:sub>2<\/jats:sub> was lower with meloxicam than robenacoxib (<jats:italic>p<\/jats:italic>\u2009=\u2009.001), and was lower in the MA than each robenacoxib group at catheter placement. Admission groups (16\/24 from RA and MA groups) received earlier rescue analgesia than other groups (<jats:italic>p<\/jats:italic>\u2009=\u2009.033). In conclusion, the renin\u2010angiotensin system was activated during anaesthesia despite cyclo\u2010oxygenase inhibition, possibly due to hypotension or surgical stimulation. There was no effect of drug or timing on the markers of renal function but one cat receiving meloxicam at induction had suspected IRIS grade II acute kidney injury.<\/jats:p>","DOI":"10.1111\/jvp.13427","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T15:14:25Z","timestamp":1705590865000},"page":"175-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of meloxicam or robenacoxib administration timing on renal function and postoperative analgesia in cats undergoing ovariohysterectomy: A randomized, blinded, controlled clinical\u00a0trial"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-1274","authenticated-orcid":false,"given":"Alex","family":"Krekis","sequence":"first","affiliation":[{"name":"Davies Veterinary Specialists  Hitchin UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan N.","family":"King","sequence":"additional","affiliation":[{"name":"J.N.King Consulting  Bennwil Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan","family":"D'Arcy\u2010Howard","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services, Beaumont Sainsbury Animal Hospital, Royal Veterinary College University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadene","family":"Stapleton","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services, Beaumont Sainsbury Animal Hospital, Royal Veterinary College University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-6590","authenticated-orcid":false,"given":"Jonathan","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, Royal Veterinary College University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6005-1975","authenticated-orcid":false,"given":"Ludovic","family":"Pelligand","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, Royal Veterinary College University of London  London UK"},{"name":"Department of Clinical Science and Services, Queen Mother Hospital for Animals, Royal Veterinary College University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2005.tb02741.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306\u20105251.2001.01533.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746\u20106148\u20109\u2010143"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2020.08.001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.685"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.1992.tb14338.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12923"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2344\/0003\u20103006\u201062.2.57"},{"key":"e_1_2_11_10_1","unstructured":"Cowgill L.(Producer). 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