{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:42:19Z","timestamp":1747186939258,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Additional immunomodulatory treatment is needed for the management of immune\u2010mediated disease in horses. Mycophenolate mofetil (MMF) is an immunomodulatory agent used in human and veterinary medicine for the prevention of graft rejection and the management of autoimmune diseases. Few studies exist investigating the pharmacokinetics of MMF in horses. The aim of this study was to evaluate the pharmacokinetics of a single dose of MMF in healthy horses in the fed vs. fasted state. Six healthy Standardbred mares were administered MMF 10\u2009mg\/kg by a nasogastric (NG) tube in a fed and fasted state. A six\u2010day washout period was performed between the two doses. No statistically significant differences in mycophenolic acid (MPA) concentrations were seen at any time point apart from 8\u2009h, when plasma metabolite concentrations were significantly higher in the fasted state compared to the fed state (<jats:italic>p<\/jats:italic>\u2009=\u2009.038). Evidence of enterohepatic recirculation was seen only in the fasted state; this did not yield clinical differences in horses administered a single\u2010dose administration but may be significant in horses receiving long\u2010term MMF treatment.<\/jats:p>","DOI":"10.1111\/jvp.13430","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T13:50:07Z","timestamp":1707486607000},"page":"280-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effects of food on the pharmacokinetics of mycophenolate mofetil in healthy horses"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7707-3545","authenticated-orcid":false,"given":"Kaitlyn","family":"Bello","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwendolen","family":"Lorch","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Papich","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeongmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics &amp; Pharmacology, College of Pharmacy The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro E.","family":"Toribio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics &amp; Pharmacology, College of Pharmacy The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiliang","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics &amp; Pharmacology, College of Pharmacy The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasey","family":"Hill","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics &amp; Pharmacology, College of Pharmacy The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitch A.","family":"Phelps","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics &amp; Pharmacology, College of Pharmacy The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010013\u20100039\u20108"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2109oa"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.13048"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102885.1992.tb01003.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13312"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102125.1996.03636.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088\u2010199834060\u201000002"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13109"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12621"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.236.6.664"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.113936"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12420"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.82.6.502"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/Fpc.0000000000000010"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2016.11.008"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.5599\/admet.1140"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.08.049"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088\u2010200241100\u201000005"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12338"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12107"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20105827.2011.01024.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.502"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.13430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T11:31:34Z","timestamp":1720438294000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.13430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,9]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/jvp.13430"],"URL":"https:\/\/doi.org\/10.1111\/jvp.13430","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"type":"print","value":"0140-7783"},{"type":"electronic","value":"1365-2885"}],"subject":[],"published":{"date-parts":[[2024,2,9]]},"assertion":[{"value":"2023-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}