{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:42:19Z","timestamp":1747186939489,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The integration of pain management in veterinary practice, driven by heightened animal welfare concerns, extends to avian species where subtle and nonspecific behavioral signs pose challenges. Given that safety concerns with classical NSAIDs highlight the need for more targeted alternatives in birds, this study explores the pharmacokinetic (PK) properties of Deracoxib (DX), a COX\u20102 selective NSAID approved for use in dogs, following a single oral administration in geese. Six healthy female geese received 4\u2009mg\/kg DX. Blood was drawn from the left wing vein to heparinized tubes at 0, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 10, and 24\u2009h. Plasma DX concentrations were measured using HPLC coupled to an UV detector, and the data were pharmacokinetically analyzed using PKanalix\u2122 software in a non\u2010compartmental approach. The results indicated a terminal half\u2010life of 6.3\u2009h and a <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub> of 1\u2009h, with no observed adverse effects. While refraining from claiming absolute safety based on a single dose, it is worth highlighting that further safety studies for DX in geese are warranted, suggesting a possibility for intermittent use. In addition, drawing conclusions on efficacy and suitability awaits further research, particularly in understanding COX\u20102 selectivity and protein binding characteristics specific to geese.<\/jats:p>","DOI":"10.1111\/jvp.13435","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T11:00:30Z","timestamp":1709204430000},"page":"231-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacokinetic evaluation of oral deracoxib in geese (<i>Anser anser domesticus<\/i>)"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9996-5942","authenticated-orcid":false,"given":"Charbel","family":"Fadel","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine University of Sassari  Sassari Italy"},{"name":"Department of Veterinary Medicine Lebanese University  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-0599","authenticated-orcid":false,"given":"Beata","family":"\u0141ebkowska\u2010Wieruszewska","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Environmental Protection University of Life Sciences  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5322-3281","authenticated-orcid":false,"given":"Amnart","family":"Poapolathep","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Medicine Kasetsart University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2147-477X","authenticated-orcid":false,"given":"Firas","family":"Serih","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Sassari  Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Bourdo","sequence":"additional","affiliation":[{"name":"PZF\u2010W Centrowet Sp.z o.o. Bia\u0142ystok  Bia\u0142ystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-4703","authenticated-orcid":false,"given":"Mario","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Sassari  Sassari Italy"},{"name":"Department of Veterinary Sciences University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532\u20100456(02)00184\u20109"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102885.2010.01185.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/03079457.2010.541421"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201012159\u2010z"},{"key":"e_1_2_7_6_1","unstructured":"EMA. (2012).Guideline on bioanalytical method validation. 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