{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:45:15Z","timestamp":1774017915697,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cinacalcet is an oral calcimimetic that has potential to non\u2010invasively treat primary hyperparathyroidism in dogs (<jats:italic>Canis lupis familiaris<\/jats:italic>). There is minimal data assessing its efficacy in dogs. This study aimed to determine whether a single dose of cinacalcet decreases serum ionized calcium (iCa), total calcium (tCa), and parathyroid hormone (PTH) concentrations. Twelve dogs received a median dose of 0.49\u2009mg\/kg (range 0.30\u20130.69\u2009mg\/kg) cinacalcet per os. Venous blood samples were collected at time 0 (before cinacalcet administration), 3, 8, and 24\u2009h following cinacalcet administration. PTH, iCa, and tCa concentrations were measured at each time point and compared to 0\u2009hour concentrations. A significant (50%) decrease in serum PTH occurred at 3\u2009h with a median PTH of 4.6\u2009pmol\/L (range 2.7\u201310.8) at baseline and 1.65\u2009pmol\/L (range 0.5\u201314.7) at 3\u2009h; <jats:italic>p<\/jats:italic>\u2009=\u2009.005. A significant, but not clinically relevant, decrease in serum iCa from a median baseline of 1.340\u2009mmol\/L (range 1.32\u20131.41) to a 3\u2009h median of 1.325\u2009mmol\/L (range 1.26\u20131.39), <jats:italic>p<\/jats:italic>\u2009=\u2009.043, was also observed. tCa concentrations were not different. This study showed that a single dose of cinacalcet leads to transient decreases in iCa and PTH concentrations in healthy dogs.<\/jats:p>","DOI":"10.1111\/jvp.13443","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:24:33Z","timestamp":1712071473000},"page":"274-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral cinacalcet administration decreases serum ionized calcium and parathyroid hormone concentrations in healthy dogs"],"prefix":"10.1111","volume":"47","author":[{"given":"Hannah E.","family":"Clark","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-7350","authenticated-orcid":false,"given":"Lauren A.","family":"Trepanier","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.IJEM_684_17"},{"key":"e_1_2_11_3_1","unstructured":"Amgen Inc. 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Available from:http:\/\/www.sensipar.com\/prescribingInfo.jsp[Accessed 2023 Jan 1]."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2007.03.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12451"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2018.1425428"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2018.09.006"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-4456-5.00015-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.756"},{"key":"e_1_2_11_10_1","first-page":"E171","article-title":"Episodic secretion of parathyroid hormone in the dog","volume":"241","author":"Fox J.","year":"1981","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2012.11.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.247.7.771"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00457.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2012.03.058"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.12.015"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018813482344"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200948050-00002"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200828100-00004"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.11.014"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.105563"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-439"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.13443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T11:31:40Z","timestamp":1720438300000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.13443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/jvp.13443"],"URL":"https:\/\/doi.org\/10.1111\/jvp.13443","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]},"assertion":[{"value":"2023-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}