{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:40:21Z","timestamp":1774690821300,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigates the pharmacokinetics (PK) of deracoxib (DX), a selective COX\u20102 inhibitor, in sheep and goats following a single oral dose. DX, approved for dogs, holds potential as an alternative NSAID in small ruminants, particularly in light of heightened concern regarding abomasal ulceration. The study employed an oral administration of DX at a dose of 150\u2009mg\/head (sheep and goats), and plasma concentrations were determined after validating a high\u2010performance liquid chromatography method, coupled to a UV detector. The PK parameters, including maximum plasma concentration (<jats:italic>C<\/jats:italic>\n<jats:sub>max<\/jats:sub>), time to reach <jats:italic>C<\/jats:italic>\n<jats:sub>max<\/jats:sub> (<jats:italic>T<\/jats:italic>\n<jats:sub>max<\/jats:sub>), elimination half\u2010life (<jats:italic>t<\/jats:italic>\n<jats:sub>1\/2<\/jats:sub>), and area under the curve (AUC), were evaluated through non\u2010compartmental analysis. Results showed detectable DX in plasma up to 48\u2009h, with no observed adverse effects. No significant differences in any PK parameters were noted between sheep and goats. Notably, <jats:italic>t<\/jats:italic>\n<jats:sub>1\/2<\/jats:sub> values were relatively long, at 16.66\u2009h for sheep and 22.86\u2009h for goats. Despite the fact that both species exhibited comparable drug exposure, high individual variability was noted within each species, suggesting to take into account individual variations in response to DX treatment, rather than species\u2010specific considerations. Additional research involving pharmacodynamics and multiple\u2010dose studies is warranted to comprehensively assess the profile of DX in these species.<\/jats:p>","DOI":"10.1111\/jvp.13444","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T09:40:39Z","timestamp":1711618839000},"page":"390-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative disposition kinetics of oral deracoxib in sheep and goats"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9996-5942","authenticated-orcid":false,"given":"Charbel","family":"Fadel","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine University of Sassari  Sassari Italy"},{"name":"Department of Veterinary Medicine Lebanese University  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-0599","authenticated-orcid":false,"given":"Beata","family":"\u0141ebkowska\u2010Wieruszewska","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Environmental Protection University of Life Sciences  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-9908","authenticated-orcid":false,"given":"Andrzej","family":"Lisowski","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Biodiversity Conservation University of Life Sciences  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2147-477X","authenticated-orcid":false,"given":"Firas","family":"Serih","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Sassari  Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5322-3281","authenticated-orcid":false,"given":"Amnart","family":"Poapolathep","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Pharmacology Kasetsart University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-4703","authenticated-orcid":false,"given":"Mario","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Sassari  Sassari Italy"},{"name":"Department of Veterinary Sciences University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118675014.ch31"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","unstructured":"Dantzler W. 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