{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:34:44Z","timestamp":1791412484103,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Parasitic infections in dairy cattle reduce herd immunity, milk production, and conception rates. This leads to higher production costs, compromised animal welfare, and increased interest in extralabel drug use. The extralabel use of anthelmintics poses food safety risks for consumers since appropriate withdrawal intervals in milk have yet to be established. Although topical eprinomectin has no milk withdrawal time, more research is needed to determine the residues present in milk after subcutaneous administration. This study aimed to characterize the pharmacokinetics of injectable eprinomectin in dry dairy cows. We hypothesized that, when given at the labeled dose, eprinomectin residues in dry dairy cattle would be below the FDA milk tolerance at the onset of lactation. Plasma was collected daily from 13 mature dairy cattle for 7\u2009days postadministration, followed by periodic samples for 90\u2009days. After calving, milk was collected daily until 90\u2009days. Eprinomectin concentrations were measured using HPLC\u2010fluorescence detection. The maximum eprinomectin concentration in plasma and milk was approximately 36\u2009ng\/mL 43\u2009h after administration and 3\u2009ng\/mL at the onset of lactation, respectively. The low eprinomectin levels in milk collected from these lactating dairy cattle suggest that administering eprinomectin at dry\u2010off is unlikely to result in violative residues. However, subcutaneous eprinomectin in lactating dairy cattle would be hard to justify unless there is evidence that the approved topical formulation is clinically ineffective.<\/jats:p>","DOI":"10.1111\/jvp.13488","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T06:18:36Z","timestamp":1729923516000},"page":"163-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Pharmacokinetics of Subcutaneous Eprinomectin in Plasma and Milk in Dry Dairy Cattle"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0379-7164","authenticated-orcid":false,"given":"Ranee A.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Population Health and Pathobiology North Carolina State University, Center of Veterinary Medicine  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyana S.","family":"McCluney","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology North Carolina State University, Center of Veterinary Medicine  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Halleran","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology North Carolina State University, Center of Veterinary Medicine  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-9338","authenticated-orcid":false,"given":"Ronald E.","family":"Baynes","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology North Carolina State University, Center of Veterinary Medicine  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek M.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology North Carolina State University, Center of Veterinary Medicine  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2016.1146172"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/rvsc.1999.0312"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1081\/E\u2010EBBE\u2010120013950"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259\u2010006\u20103230\u20107"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.666348"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11102878"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304\u20104017(01)00439\u20103"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12840"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2020.109157"},{"key":"e_1_2_10_11_1","unstructured":"European Medicines Agency (EMA).2017. \u201cReflection Paper on Anthelmintic Resistance.\u201dhttps:\/\/www.ema.europa.eu\/en\/documents\/scientific\u2010guideline\/reflection\u2010paper\u2010anthelmintic\u2010resistance_en.pdf\u20101."},{"key":"e_1_2_10_12_1","unstructured":"Food and Drug Administration (FDA).2015. \u201cGuidance for Industry Studies to Evaluate the Metabolism and Residue Kinetics of Veterinary Drugs in Food\u2010Producing Animals: Marker Residue Depletion Studies to Establish Product Withdrawal Periods VICH GL48(R).\u201dhttps:\/\/www.fda.gov\/media\/78351\/download."},{"key":"e_1_2_10_13_1","first-page":"296","article-title":"Effectiveness of Current Anthelmintic Treatment Programs on Reducing Fecal Egg Counts in United States Cow\u2010Calf Operations","volume":"79","author":"Gasbarre L. C.","year":"2015","journal-title":"Canadian Journal of Veterinary Research"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.144.21.581"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11102758"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0020\u20107519(01)00285\u20105"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2015.11.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304\u20104017(99)00142\u20109"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12341"},{"key":"e_1_2_10_20_1","unstructured":"R Core Team.2023. \u201cR: A language and environment for statistical computing.\u201d R Foundation for Statistical Computing Vienna Austria.https:\/\/www.R\u2010project.org\/."},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.1047497"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2004.01.006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2012.11.037"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodqual.2020.103872"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/tas\/txz015"}],"container-title":["Journal of Veterinary Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.13488","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvp.13488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T01:25:38Z","timestamp":1747013138000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvp.13488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,26]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jvp.13488"],"URL":"https:\/\/doi.org\/10.1111\/jvp.13488","archive":["Portico"],"relation":{},"ISSN":["0140-7783","1365-2885"],"issn-type":[{"value":"0140-7783","type":"print"},{"value":"1365-2885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,26]]},"assertion":[{"value":"2024-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}