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Here, we estimated the pharmacokinetic parameters of salbutamol after a single intravenous (IV) or IH administration in six horses, and we statistically analysed the detection times with various dosing regimens. Plasma and urine concentrations of salbutamol were measured by liquid chromatography\u2013tandem mass spectrometry, and data were modelled by using a nonlinear mixed effect model followed by Monte Carlo simulation (MCS). With IH salbutamol, the maximum plasma concentration was 0.12\u2009\u00b1\u20090.06\u2009ng\/mL at 0.29\u2009\u00b1\u20090.17\u2009h after administration. Typical values were, for clearance, 1.53\u2009L\/kg\/h; distribution volume at steady state, 5.43\u2009L\/kg; terminal half\u2010life, 6.06\u2009h; IH bioavailability, 19.0%; and urine to plasma ratio, 2057. Statistically estimated 95th percentile detection times in the urine at levels below the international screening limit (0.5\u2009ng\/mL) proposed by the International Federation of Horseracing Authorities, as simulated in 5000 horses by MCS, were 44\u2009h after 1.6\u2009\u03bcg\/kg q 24 and 54\u2009h after 1.6\u2009\u03bcg\/kg q 4\u2009h over a 3\u2010day IH administration period.<\/jats:p>","DOI":"10.1111\/jvp.13491","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T03:48:54Z","timestamp":1731383334000},"page":"76-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacokinetics of Salbutamol in Thoroughbred Horses After a Single Intravenous or Inhaled Administration"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-9625","authenticated-orcid":false,"given":"Motoi","family":"Nomura","sequence":"first","affiliation":[{"name":"Equine Research Institute Japan Racing Association  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3709-5459","authenticated-orcid":false,"given":"Taisuke","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Equine Research Institute Japan Racing Association  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-5044","authenticated-orcid":false,"given":"Minoru","family":"Ohta","sequence":"additional","affiliation":[{"name":"Equine Research Institute Japan Racing Association  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-9135","authenticated-orcid":false,"given":"Kanichi","family":"Kusano","sequence":"additional","affiliation":[{"name":"Equine Department Japan Racing Association  Minato Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2096-0784","authenticated-orcid":false,"given":"Yohei","family":"Minamijima","sequence":"additional","affiliation":[{"name":"Laboratory of Racing Chemistry  Utsunomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Nagata","sequence":"additional","affiliation":[{"name":"Laboratory of Racing Chemistry  Utsunomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.supplement_2.13tac800"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20103306.2010.00313.x"},{"key":"e_1_2_10_4_1","first-page":"340","article-title":"The Elimination Time of Albuterol Administered as an Inhalant and as an Oral Syrup to Athletically Conditioned Thoroughbred Horses","volume":"36","author":"Colahan P.","year":"2004","journal-title":"Proceedings of the15th International Conference of Racing Analysts and Veterinarians"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920012800166571"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1999.60.06.689"},{"issue":"3","key":"e_1_2_10_7_1","first-page":"297","article-title":"Apparent ELISA Detection Times for Albuterol After Administration With the Torpex Equine Inhaler Device","volume":"3","author":"Dirikolu L.","year":"2002","journal-title":"Veterinary Therapeutics"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.1999.tb00933.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.194"},{"key":"e_1_2_10_10_1","unstructured":"Hansson E. 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