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The apparent distribution volume of the central compartment (V<jats:sub>1<\/jats:sub>), apparent distribution volume of the peripheral compartment (V<jats:sub>2<\/jats:sub>), CL, and clearance from the central compartment to the peripheral compartment (CL<jats:sub>2<\/jats:sub>) were estimated to be 0.42, 2.05\u2009L\/kg, 0.067, and 2.94\u2009L\/h\/kg, respectively. Finally, the bioavailability was calculated to be 84.81%. The parameter of AUC\/minimum inhibitory concentration value was estimated to be more than 506.32 for <jats:styled-content style=\"fixed-case\"><jats:italic>Aeromonas hydrophila<\/jats:italic><\/jats:styled-content>, <jats:styled-content style=\"fixed-case\"><jats:italic>Aeromonas sobria<\/jats:italic><\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\"><jats:italic>Flavobacterium columnare<\/jats:italic><\/jats:styled-content> indicating that EF at 20\u2009mg\/kg has high effectiveness for these pathogens. This study supported a concise method for conducting PK study in aquatic animals that facilitated the development of PK methodology in aquaculture.<\/jats:p>","DOI":"10.1111\/jvp.13497","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T11:10:12Z","timestamp":1736766612000},"page":"201-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Population Pharmacokinetics of Enrofloxacin in <i>Ctenopharyngodon idella<\/i> Based on the Sparse Sampling Method and a Nonlinear Mixed Effect Model Following Intravenous and Oral Administration"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-5216","authenticated-orcid":false,"given":"Ning","family":"Xu","sequence":"first","affiliation":[{"name":"Yangtze River Fisheries Research Institute Chinese Academy of Fishery Sciences  Wuhan China"},{"name":"Hu Bei Province Engineering and Technology Research 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