{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:46:58Z","timestamp":1785383218945,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Isavuconazole, a triazole antifungal used in humans for invasive fungal infections, may be effective for treating canine fungal infections, although data on its use in dogs is limited. This study aimed to determine the pharmacokinetics and safety of a single dose of isavuconazole in dogs, administered both intravenously and orally. Six healthy dogs received 186\u2009mg isavuconazonium sulfate in a crossover design, with blood samples collected over 28\u2009days and an 8\u2010week washout period. Plasma isavuconazole and isavuconazonium concentrations were measured by liquid chromatography\/mass spectrometry, and pharmacokinetic parameters were determined by non\u2010compartmental analysis. Isavuconazole was well tolerated, with key findings including intravenous clearance at 350\u2009\u00b1\u2009112\u2009mL\/kg\/h, volume of distribution at steady state at 9.8\u2009\u00b1\u20094.5\u2009L\/kg, and a terminal half\u2010life of 90\u2009\u00b1\u200944\u2009h. For oral administration, the maximum concentration was 0.60\u2009\u00b1\u20090.27\u2009\u03bcg\/mL, time to maximum concentration was 6.73\u2009\u00b1\u20092.45\u2009h, terminal half\u2010life was 125\u2009\u00b1\u200980\u2009h, and the area under the curve was 7.44\u2009\u00b1\u20092.39\u2009\u03bcg\u2009h\/mL. Oral bioavailability was 81.4%\u2009\u00b1\u200912.8%. These results suggest isavuconazole has a long half\u2010life in dogs and is well absorbed orally when administered in the fasted state. Further studies are warranted to establish a therapeutic regimen in dogs.<\/jats:p>","DOI":"10.1111\/jvp.13510","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T02:57:45Z","timestamp":1744167465000},"page":"234-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Single\u2010Dose, Intravenous, and Oral Pharmacokinetics of Isavuconazole in Dogs"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3918-0381","authenticated-orcid":false,"given":"Yishan","family":"Kuo","sequence":"first","affiliation":[{"name":"The Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[{"name":"The Duke Proteomics and Metabolomics Core Facility Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Forsythe","sequence":"additional","affiliation":[{"name":"The Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-5075","authenticated-orcid":false,"given":"Jennifer M.","family":"Reinhart","sequence":"additional","affiliation":[{"name":"The Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00585\u201018"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010\u2010017\u20101042\u2010z"},{"key":"e_1_2_11_4_1","volume-title":"Small Animal Clinical Pharmacology and Therapeutics","author":"Boothe D. 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