{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:20:00Z","timestamp":1792189200733,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The objective of this investigation was to ascertain the impact of gender on the pharmacokinetics of meloxicam in sheep. The research was carried out on six female and six male Romanov sheep. Meloxicam was administered intravenously to sheep at a dose of 1\u2009mg\/kg. To determine the change in meloxicam concentration with time, blood samples were collected at 17 different time points up to 120\u2009h after administration. Meloxicam concentrations in plasma samples were determined using high\u2010performance liquid chromatography. The pharmacokinetics of meloxicam in sheep was found to differ according to gender. The values of total clearance (Cl\n                    <jats:sub>T<\/jats:sub>\n                    ), volume of distribution at steady state (\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>dss<\/jats:sub>\n                    ), and elimination half\u2010life (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2\u03bbz<\/jats:sub>\n                    ) of meloxicam in female sheep were 4.51\u2009\u00b1\u20090.56\u2009mL\/h\/kg, 69.18\u2009\u00b1\u20096.68\u2009mL\/kg, and 11.96\u2009\u00b1\u20090.33\u2009h, respectively. Compared to female sheep, Cl\n                    <jats:sub>T<\/jats:sub>\n                    and\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>dss<\/jats:sub>\n                    were increased, and\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2\u03bbz<\/jats:sub>\n                    was decreased in male sheep. Plasma concentration and area under the curve of meloxicam were higher in female sheep. The findings of this study indicate that meloxicam's pharmacokinetics are not uniform across genders in Romanov sheep, with notable variations in plasma concentration, clearance, and half\u2010life. These variations emphasize the importance of considering gender in the pharmacotherapy of sheep, potentially guiding clinicians in adjusting dosages for optimal therapeutic outcomes and maintaining food safety standards.\n                  <\/jats:p>","DOI":"10.1111\/jvp.70005","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T06:19:38Z","timestamp":1749190778000},"page":"468-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Gender on the Pharmacokinetics of Meloxicam in Sheep"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-2510","authenticated-orcid":false,"given":"Orhan","family":"Corum","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Hatay Mustafa Kemal  Antakya Hatay T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8674-4873","authenticated-orcid":false,"given":"Kamil","family":"Uney","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Selcuk  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-991X","authenticated-orcid":false,"given":"Duygu","family":"Durna Corum","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Hatay Mustafa Kemal  Antakya Hatay T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1151-1861","authenticated-orcid":false,"given":"Devran","family":"Coskun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Siirt  Siirt T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8875-7894","authenticated-orcid":false,"given":"Fatma","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Siirt  Siirt T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9236-0630","authenticated-orcid":false,"given":"Halis","family":"Oguz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Selcuk  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9059-7151","authenticated-orcid":false,"given":"Muammer","family":"Elmas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Selcuk  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10601330500214559"},{"key":"e_1_2_9_3_1","first-page":"15","volume-title":"Veterinary Pharmacology and Therapeutics","author":"Brown S. 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