{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:40:09Z","timestamp":1774690809275,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    There is a shifting public perception of animal welfare that has increased demand for establishing pain management strategies in livestock. Gabapentin is often utilized in practice to mitigate neuropathic pain. However, there is little pharmacokinetic information to guide its use in goats. The objectives of this study were to describe the pharmacokinetics of oral gabapentin in goats given as a single dose (SD) and multidose (MD) regimen, as well as to document any adverse effects after administration. Six healthy adult goats were administered 15\u2009mg\/kg of gabapentin orally once for the SD trial, and every 12\u2009h for 6 doses for the MD trial. Plasma samples were collected and analyzed via reversed\u2010phase high\u2010performance liquid chromatography. After SD administration, maximum plasma concentration, time to maximum concentration, and elimination half\u2010life were: 3.22\u2009\u03bcg\/mL; 4.49\u2009h; and 8.15\u2009h, respectively. After MD administration, maximum plasma concentration and time to maximum concentration were: 4.56\u2009\u03bcg\/mL and 2.24\u2009h. Accumulation ratio (R) was 1.66\u2009\u00b1\u20090.81 when comparing the MD AUC12\n                    <jats:sub>h<\/jats:sub>\n                    to the SD AUC12\n                    <jats:sub>h<\/jats:sub>\n                    . Clinicians should be aware of the potential for increased accumulation ratio with multiple dosing strategies.\n                  <\/jats:p>","DOI":"10.1111\/jvp.70006","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T07:19:27Z","timestamp":1749712767000},"page":"491-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacokinetics of Single Dose and Multidose Oral Gabapentin in Goats (\n                    <i>Capra aegagrus hircus<\/i>\n                    )"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-8388","authenticated-orcid":false,"given":"Jessie C.","family":"Ziegler","sequence":"first","affiliation":[{"name":"Farm Animal Medicine and Surgery College of Veterinary Medicine, Midwestern University  Glendale Arizona 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15313"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10030385"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12473"},{"key":"e_1_2_11_5_1","unstructured":"Chew on this: Goats as pets.2020.\u201cTexas A&M University Veterinary Medicine & Biomedical Sciences: News & 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