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The main strategy to control fasciolosis in livestock animals, is based on drugs such as triclabendazole (TCBZ), albendazole (ABZ), clorsulon (CLOR), nitroxynil, closantel, and rafoxanide. Only TCBZ is available for\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>F. hepatica<\/jats:italic>\n                    <\/jats:styled-content>\n                    control in human medicine and its resistance is growing. The use of drug combinations has been proposed as a strategy to delay it. This study compares the pharmacokinetics and flukicidal efficacy of ABZ\u2009+\u2009CLOR when administered together or separately in sheep infected with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>F. hepatica<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Enhanced systemic exposure of the ABZ sulphoxide metabolite was observed after the co\u2010administration ABZ\u2009+\u2009CLOR compared to the ABZ alone treatment. The CLOR disposition kinetics was not affected by its co\u2010administration with ABZ. The flukicidal clinical efficacy was 85% (ABZ), 92% (CLOR) and 100% (ABZ\u2009+\u2009CLOR), respectively. The work described here contributes to the characterization of the disposition kinetics of both flukicidal molecules showing that the combined ABZ and CLOR therapy may enhance the efficacy against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>F. hepatica<\/jats:italic>\n                    <\/jats:styled-content>\n                    in sheep.\n                  <\/jats:p>","DOI":"10.1111\/jvp.70009","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T04:23:40Z","timestamp":1750825420000},"page":"474-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Albendazole and Clorsulon in\n                    <i>Fasciola hepatica<\/i>\n                    Control: Integrated Pharmacokinetic and Flukicidal Eficacy Assessment in Sheep"],"prefix":"10.1111","volume":"48","author":[{"given":"V.","family":"Chiappetta","sequence":"first","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN), UNCPBA\u2010CICPBA\u2010CONICET Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias  Tandil, Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cant\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN), UNCPBA\u2010CICPBA\u2010CONICET Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias  Tandil, Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pruzzo","sequence":"additional","affiliation":[{"name":"Centro de Diagn\u00f3stico Veterinario (CEDIVE), Facultad de Ciencias Veterinarias Universidad Nacional de La Plata  Chascom\u00fas, Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lanusse","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN), UNCPBA\u2010CICPBA\u2010CONICET Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias  Tandil, Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN), UNCPBA\u2010CICPBA\u2010CONICET Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias  Tandil, Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-2438","authenticated-orcid":false,"given":"L.","family":"Ceballos","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN), UNCPBA\u2010CICPBA\u2010CONICET Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias  Tandil, Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2008.00953.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304\u20104017(00)00320\u20104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.159.13.424"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.455"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1988.tb07355.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1991.tb03154.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.669"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.11.030"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.1996.tb03965.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1268658"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.113.14.315"},{"key":"e_1_2_9_13_1","first-page":"83","volume-title":"Immunology, Pathobiology and Control of Fasciolosis","author":"Boray J. 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