{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:22:37Z","timestamp":1773037357911,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["2020\u201067015\u201031546"],"award-info":[{"award-number":["2020\u201067015\u201031546"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp; Therapeutics"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The objective of this study was to determine and compare the pharmacokinetics of oral firocoxib, oral meloxicam, and transdermal flunixin (TD) in 44 adult, male castrated, crossbred goats. Pharmacokinetic (PK) analysis was performed for each goat in each phase using non\u2010compartmental methods with descriptive statistics reported. Mean plasma half\u2010life (T\n                    <jats:sub>1\/2<\/jats:sub>\n                    (h)) for oral (PO) administration of firocoxib at varying dosages in meat type castrated goats was reported at 0.5\u2009mg\/kg, 1.0\u2009mg\/kg, and 2.0\u2009mg\/kg at 9.1 (range 6.9\u201313.4), 10.2 (range 6.4\u201314.7) and 9.2 (range 6.8\u201312.8), respectively. For oral meloxicam, mean plasma T\n                    <jats:sub>1\/2<\/jats:sub>\n                    at doses of 1.0\u2009mg\/kg, 2.0\u2009mg\/kg, and 3.0\u2009mg\/kg were 13.3 (range: 10.1\u201322.3), 13.1 (range: 12\u201324), and 11.7 (range: 8.3\u201320.5) hours, respectively. Transdermal flunixin showed mean plasma T\n                    <jats:sub>1\/2<\/jats:sub>\n                    of 16.5 (range: 10.7\u201362) at 3.3\u2009mg\/kg, 22.0 (range: 16.6\u201367.4) at 4.2\u2009mg\/kg, and 17.8 (range: 7.4\u201356.3) at 5.0\u2009mg\/kg. These results highlight significant variability in drug disposition and suggest that further research is warranted to optimize dosing regimens for oral firocoxib, oral meloxicam, and transdermal flunixin in goats.\n                  <\/jats:p>","DOI":"10.1111\/jvp.70035","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:55:22Z","timestamp":1764590122000},"page":"172-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetic Parameters of Oral Firocoxib, Oral Meloxicam, and Transdermal Flunixin in Meat Type Goats"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4878-0769","authenticated-orcid":false,"given":"Mikaela M.","family":"Weeder","sequence":"first","affiliation":[{"name":"Department of Anatomy and Physiology, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-3657","authenticated-orcid":false,"given":"Michael D.","family":"Kleinhenz","sequence":"additional","affiliation":[{"name":"Veterinary Education, Research, and Outreach (VERO), College of Veterinary and Biomedical Sciences Texas A&amp;M University  Canyon Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6833-3237","authenticated-orcid":false,"given":"Christopher T.","family":"Culbertson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Arts and Sciences Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily J.","family":"Reppert","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9027-6583","authenticated-orcid":false,"given":"Kushan","family":"Kompalage","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"},{"name":"Department of Chemistry, College of Arts and Sciences Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"},{"name":"Department of Chemistry, College of Arts and Sciences Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misty","family":"Bear","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3087-2841","authenticated-orcid":false,"given":"Andrew K.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ally A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bailey R.","family":"Fritz","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payton","family":"Dahmer","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, College of Agriculture Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-3991","authenticated-orcid":false,"given":"Johann F.","family":"Coetzee","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology, College of Veterinary Medicine Kansas State University  Manhattan Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2019.01.013"},{"key":"e_1_2_11_3_1","unstructured":"Corporation W.2024.Oasis Cartridges and 96\u2010Well Plates Care and Use 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