{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:12:16Z","timestamp":1788880336040,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp;amp; Therapeutics"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The anti\u2010parasitic drug moxidectin is a frontline treatment for sarcoptic mange in bare\u2010nosed wombats (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Vombatus ursinus<\/jats:italic>\n                    <\/jats:styled-content>\n                    ), a disease causing significant animal welfare issues and instances of local population declines. Despite widespread usage, knowledge of species\u2010specific pharmacokinetics of moxidectin in bare\u2010nosed wombats is still limited. This study describes the clinical pharmacokinetics of moxidectin by intravenous, subcutaneous, and transdermal routes of administration in bare\u2010nosed wombats. Plasma moxidectin concentration was assessed by liquid chromatography mass spectrometry and analysed by Bayesian hierarchical modelling. Plasma clearance was 1.11\u20131.85\u2009mL\/min\/kg. The subcutaneous route showed biphasic absorption, dominated by a slow terminal absorption phase (80% of the effective dose of moxidectin was absorbed in this phase) with a half\u2010life of approximately 631\u2009h (26.3\u2009days). The transdermal route had an estimated half\u2010life of 21.78\u2009h (1308) min. The average bioavailability was 0.59% and 95.7% by the transdermal and subcutaneous route, respectively. This detailed insight into the pharmacokinetics of moxidectin in bare\u2010nosed wombats provides a crucial foundation for the design of treatment regimens, whilst also highlighting the inefficiency of transdermal delivery.\n                  <\/jats:p>","DOI":"10.1111\/jvp.70074","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:57:14Z","timestamp":1776412634000},"page":"533-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacokinetics of Moxidectin in Bare\u2010Nosed Wombats (\n                    <i>Vombatus ursinus<\/i>\n                    ) After Intravenous, Sub\u2010Cutaneous and Transdermal Administration"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3818-9411","authenticated-orcid":false,"given":"E. 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