{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:58:44Z","timestamp":1790607524173,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010282","name":"Harry M. Zweig Memorial Fund for Equine Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010282","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Pharm &amp;amp; Therapeutics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ursodeoxycholic acid (UDCA) is a secondary bile acid used in humans for the treatment of some cholestatic diseases. Interest in its potential use in equine patients with liver conditions has increased. Pharmacokinetic parameters in adult horses have recently been reported; however, they are not available for foals. The objective of this study was to characterize the pharmacokinetics of UDCA following a single oral dose of 15\u2009mg\/kg in six healthy neonatal foals and evaluate associated changes in bile acids (BA) profile. UDCA concentrations were measured using liquid chromatography\u2013tandem mass spectrometry. Pharmacokinetic analysis demonstrated median peak concentration (\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    ) of 23.74\u2009\u03bcmol (range 12.86\u201338.02\u2009\u03bcmol) obtained at 5.5\u2009h (range 2\u20136\u2009h) (\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    ). Concentrations declined by 24\u2009h post\u2010dosing, with minimal levels detected between 48 and 72\u2009h. The median half\u2010life was calculated to be 10.32\u2009h (range 8.05\u201319.12\u2009h), and the estimated mean dosing interval was approximately 12\u2009h. Following administration, plasma UDCA concentrations increased substantially, with marked shift in BA profiles resulting in an increase in the proportion of UDCA relative to other BAs. These results suggest that an oral UDCA dose of 15\u2009mg\/kg administered every 12\u2009h is likely appropriate for neonatal foals.\n                  <\/jats:p>","DOI":"10.1111\/jvp.70111","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:28:37Z","timestamp":1790605717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ursodeoxycholic Acid Oral Pharmacokinetics and Plasma Bile Acid Profile Changes in a Population of Healthy Neonatal Foals"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0689-6297","authenticated-orcid":false,"given":"T. N.","family":"Burdette","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Cornell University  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2080-8002","authenticated-orcid":false,"given":"B.","family":"Delvescovo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cornell University  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Wise Bellin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cornell University  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Divers","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cornell University  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1503-1419","authenticated-orcid":false,"given":"C. G.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cornell University  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176\u2010199705000\u201000016"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2007.tb02998.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00121.2015"},{"key":"e_1_2_11_5_1","unstructured":"Divers T. J.2015.\u201cThe Equine Liver in Health and Disease.\u201d AAEP Proceedings 2015."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2026.1714100"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201015338\u20100"},{"key":"e_1_2_11_8_1","unstructured":"FDA.1997.\u201cFDA Approval.\u201dhttps:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/020675s028lbl.pdf."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics3010053"},{"issue":"1","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1053\/gast.2001.25542","article-title":"Effects of Ursodeoxycholic and Cholic Acid Feeding on Hepatocellular Transporter Expression in Mouse Liver","volume":"121","author":"Fickert P.","year":"2001","journal-title":"Gastroenterology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280691"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519\u2010022\u201000563\u2010z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0168\u20108278(01)00092\u20107"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.70048"},{"issue":"6","key":"e_1_2_11_15_1","first-page":"690","article-title":"Dissolution of Cholesterol Gallstones by Long\u2010Term Administration of Ursodeoxycholic Acid","volume":"72","author":"Makino I.","year":"1975","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.14195"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2008.0171.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23631"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940\u20106207.CAPR\u201009\u20100234"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201090687\u20105"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246161"},{"issue":"17","key":"e_1_2_11_22_1","first-page":"107","article-title":"Review on Chinese Pharmacology and Clinical Application of Bear Bile","volume":"12","author":"Zhang Y. 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