{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:45:11Z","timestamp":1769741111444,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Caenorhabditis Genetics Center"},{"name":"NIH Office of Research Infrastructure Programs","award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}]},{"name":"National Basic Research Program (973) of China","award":["2013CB127504"],"award-info":[{"award-number":["2013CB127504"]}]},{"name":"National High Technology Research and Development Program (863) of China","award":["2011AA10A203"],"award-info":[{"award-number":["2011AA10A203"]}]},{"name":"Innovation Platform Open Foundation of Higher Education Institutions of Hunan Province, China","award":["09K023"],"award-info":[{"award-number":["09K023"]}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"crossref","award":["20114306120006"],"award-info":[{"award-number":["20114306120006"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Industrialization Research Foundation of Education Bureau of Hunan Province, China","award":["11CY024"],"award-info":[{"award-number":["11CY024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lett Appl Microbiol"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1111\/lam.12219","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T16:25:03Z","timestamp":1390407903000},"page":"511-519","source":"Crossref","is-referenced-by-count":21,"title":["<i>Bacillus thuringiensis<\/i>Cry6A exhibits nematicidal activity to<i>Caenorhabditis elegans bre<\/i>mutants and synergistic activity with Cry5B to<i>C<\/i>.\u00a0<i>elegans<\/i>"],"prefix":"10.1093","volume":"58","author":[{"given":"Z.","family":"Yu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Breeding Base of Microbial Molecular Biology; The Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province; College of Life Science; Hunan Normal University; Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Breeding Base of Microbial Molecular Biology; The Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province; College of Life Science; Hunan Normal University; Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Breeding Base of Microbial Molecular Biology; The Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province; College of Life Science; Hunan Normal University; Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Breeding Base of Microbial Molecular Biology; The Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province; College of Life Science; Hunan Normal University; Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Breeding Base of Microbial Molecular Biology; The Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province; College of Life Science; Hunan Normal University; Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology; College of Life Science and Technology; Huazhong Agricultural University; Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology; College of Life Science and Technology; Huazhong Agricultural University; Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology; College of Life Science and Technology; Huazhong Agricultural University; Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"10.1111\/lam.12219-BIB0001|lam12219-cit-0001","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1074\/jbc.M606621200","article-title":"Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose","volume":"282","author":"Barrows","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1111\/lam.12219-BIB0002|lam12219-cit-0002","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1385\/1-59745-151-7:139","volume-title":"C. elegans Methods and Application","author":"Bischof","year":"2006"},{"key":"10.1111\/lam.12219-BIB0003|lam12219-cit-0003","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1111\/lam.12219-BIB0004|lam12219-cit-0004","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.toxicon.2006.11.022","article-title":"Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control","volume":"49","author":"Bravo","year":"2007","journal-title":"Toxicon"},{"key":"10.1111\/lam.12219-BIB0005|lam12219-cit-0005","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ibmb.2011.02.006","article-title":"Bacillus thuringiensis: a story of a successful bioinsecticide","volume":"41","author":"Bravo","year":"2011","journal-title":"Insect Biochem Mol Biol"},{"key":"10.1111\/lam.12219-BIB0006|lam12219-cit-0006","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1111\/lam.12219-BIB0007|lam12219-cit-0007","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.peptides.2010.06.005","article-title":"Binding of Bacillus thuringiensis subsp. israelensis Cry4Ba to Cyt1Aa has an important role in synergism","volume":"32","author":"Cant\u00f3n","year":"2011","journal-title":"Peptides"},{"key":"10.1111\/lam.12219-BIB0008|lam12219-cit-0008","first-page":"663","article-title":"Synergistic effect of Cry1Ac and Cry1F delta-endotoxins of Bacillus thuringiensis on cotton bollworm, Helicoverpa armigera","volume":"75","author":"Chakrabarti","year":"1998","journal-title":"Curr Sci"},{"key":"10.1111\/lam.12219-BIB0009|lam12219-cit-0009","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1128\/MMBR.62.3.807-813.1998","article-title":"Revision of the nomenclature for the Bacillus thuringiensis pesticidal crystal proteins","volume":"62","author":"Crickmore","year":"1998","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1111\/lam.12219-BIB0010|lam12219-cit-0010","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.1128\/AEM.00532-09","article-title":"Bacillus thuringiensis Bel protein enhances the toxicity of Cry1Ac protein to Helicoverpa armigera larvae by degrading insect intestinal mucin","volume":"75","author":"Fang","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"10.1111\/lam.12219-BIB0011|lam12219-cit-0011","first-page":"271","article-title":"Bacillus thuringiensis: insects and beyond","volume":"10","author":"Feitelson","year":"1992","journal-title":"Bio\/Technology"},{"key":"10.1111\/lam.12219-BIB0012|lam12219-cit-0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jip.2009.02.009","article-title":"Insecticidal activity of Bacillus thuringiensis crystal proteins","volume":"101","author":"Frankenhuyzen","year":"2009","journal-title":"J Invertebr Pathol"},{"key":"10.1111\/lam.12219-BIB0013|lam12219-cit-0013","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1126\/science.1062441","article-title":"Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme","volume":"293","author":"Griffitts","year":"2001","journal-title":"Science"},{"key":"10.1111\/lam.12219-BIB0014|lam12219-cit-0014","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1126\/science.1104444","article-title":"Glycolipids as receptors for Bacillus thuringiensis crystal toxin","volume":"307","author":"Griffitts","year":"2005","journal-title":"Science"},{"key":"10.1111\/lam.12219-BIB0015|lam12219-cit-0015","doi-asserted-by":"crossref","first-page":"6997","DOI":"10.1128\/AEM.01346-08","article-title":"New strategy for isolating novel nematicidal crystal protein genes from Bacillus thuringiensis strain YBT-518","volume":"74","author":"Guo","year":"2008","journal-title":"Appl Environ Microbiol"},{"key":"10.1111\/lam.12219-BIB0016|lam12219-cit-0016","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1128\/AEM.00409-09","article-title":"Parasporal body formation via overexpression of the Cry10Aa toxin of Bacillus thuringiensis subsp. israelensis, and Cry10Aa-Cyt1Aa synergism","volume":"75","author":"Hern\u00e1ndez-Soto","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"10.1111\/lam.12219-BIB0017|lam12219-cit-0017","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1128\/MR.53.2.242-255.1989","article-title":"Insecticidal crystal proteins of Bacillus thuringiensis","volume":"53","author":"H\u00f6fte","year":"1989","journal-title":"Microbiol Rev"},{"key":"10.1111\/lam.12219-BIB0018|lam12219-cit-0018","doi-asserted-by":"crossref","first-page":"9911","DOI":"10.1021\/bi301386q","article-title":"Structure and glycolipid binding properties of the nematicidal protein Cry5B","volume":"51","author":"Hui","year":"2012","journal-title":"Biochemistry"},{"key":"10.1111\/lam.12219-BIB0019|lam12219-cit-0019","first-page":"641","article-title":"Bacillus thuringiensis (Bt) transgenic crop: an environment friendly insect-pest management strategy","volume":"29","author":"Kumar","year":"2008","journal-title":"J Environ Biol"},{"key":"10.1111\/lam.12219-BIB0020|lam12219-cit-0020","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/AEM.62.2.583-586.1996","article-title":"Synergistic effect of the Bacillus thuringiensis toxins CryIAa and CryIAc on the gypsy moth, Lymantria dispar","volume":"62","author":"Lee","year":"1996","journal-title":"Appl Environ Microbiol"},{"key":"10.1111\/lam.12219-BIB0021|lam12219-cit-0021","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1467-7652.2007.00257.x","article-title":"Resistance to root-knot nematode in tomato roots expressing a nematicidal Bacillus thuringiensis crystal protein","volume":"5","author":"Li","year":"2007","journal-title":"Plant Biotechnol J"},{"key":"10.1111\/lam.12219-BIB0022|lam12219-cit-0022","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.biocontrol.2008.06.007","article-title":"Expression of Cry5B protein from Bacillus thuringiensis in plant roots confers resistance to root-knot nematode","volume":"47","author":"Li","year":"2008","journal-title":"Biol Control"},{"key":"10.1111\/lam.12219-BIB0023|lam12219-cit-0023","doi-asserted-by":"crossref","first-page":"10135","DOI":"10.1007\/s00253-013-5249-3","article-title":"The effects of Bacillus thuringiensis Cry6A on the survival, growth, reproduction, locomotion, and behavioral response of Caenorhabditis elegans","volume":"97","author":"Luo","year":"2013","journal-title":"Appl Micriobiol Biotechnol"},{"key":"10.1111\/lam.12219-BIB0024|lam12219-cit-0024","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1093\/genetics\/155.4.1693","article-title":"Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans","volume":"155","author":"Marroquin","year":"2000","journal-title":"Genetics"},{"key":"10.1111\/lam.12219-BIB0025|lam12219-cit-0025","first-page":"427","article-title":"Parasporin, a new anticancer protein group from Bacillus thuringiensis","volume":"29","author":"Ohba","year":"2009","journal-title":"Anticancer Res"},{"key":"10.1111\/lam.12219-BIB0026|lam12219-cit-0026","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1751-7915.2011.00295.x","article-title":"Synergistic activity between Bacillus thuringiensis against Meloidogyne incognita","volume":"4","author":"Peng","year":"2011","journal-title":"Microb Biotechnol"},{"key":"10.1111\/lam.12219-BIB0027|lam12219-cit-0027","doi-asserted-by":"crossref","first-page":"18303","DOI":"10.1073\/pnas.0505494102","article-title":"Bacillus thuringiensis susp. israelensis Cyt1Aa synergizes Cry11Aa toxin by functioning as a membrane-bound receptor","volume":"102","author":"Perez","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/lam.12219-BIB0028|lam12219-cit-0028","first-page":"547","article-title":"Bacillus thuringiensis as a specific, safe, and effective tool for insect pest control","volume":"17","author":"Roh","year":"2007","journal-title":"J Microbiol Biotechnol"},{"key":"10.1111\/lam.12219-BIB0029|lam12219-cit-0029","volume-title":"Molecular Cloning: a Laboratory Manual","author":"Sambrook","year":"2001"},{"key":"10.1111\/lam.12219-BIB0030|lam12219-cit-0030","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1128\/MMBR.62.3.775-806.1998","article-title":"Bacillus thuringiensis and its pesticidal crystal proteins","volume":"62","author":"Schnepf","year":"1998","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1111\/lam.12219-BIB0031|lam12219-cit-0031","first-page":"42","article-title":"Synergistic activity between Bacillus thuringiensis Cry1Ab and Cry1Ac toxins against maize stem borer (Chilo partellus Swinhoe)","volume":"51","author":"Sharma","year":"2010","journal-title":"Lett Appl Microbiol"},{"key":"10.1111\/lam.12219-BIB0032|lam12219-cit-0032","unstructured":"Soares , C.G. Everich , R.C. Payne , J. 1989 Novel isolates of Bacillus thuringiensis having activity against the alfalfa weevil, Hypera brunneipennis"},{"key":"10.1111\/lam.12219-BIB0033|lam12219-cit-0033","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1128\/AEM.58.10.3343-3346.1992","article-title":"Evaluation of synergism among Bacillus thuringiensis toxins","volume":"58","author":"Tabashnik","year":"1992","journal-title":"Appl Environ Microbiol"},{"key":"10.1111\/lam.12219-BIB0034|lam12219-cit-0034","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.phyto.39.1.53","article-title":"Apomictic, polyphagous root-knot nematodes: exceptionally successful and damaging biotrophic root pathogens","volume":"39","author":"Trudgill","year":"2001","journal-title":"Annu Rev Phytopathol"},{"key":"10.1111\/lam.12219-BIB0035|lam12219-cit-0035","unstructured":"Uyeda , K.A. Foncerada , L. Payne , J.M. Narva , K.E. Schwab , G.E. Bradfisch , G.A. Sick , A.J. 1994 Process for controlling lepidopteran pests"},{"key":"10.1111\/lam.12219-BIB0036|lam12219-cit-0036","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1073\/pnas.0538072100","article-title":"Bacillus thuringiensis crystal proteins that target nematodes","volume":"100","author":"Wei","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/lam.12219-BIB0037|lam12219-cit-0037","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1472-765X.2005.01712.x","article-title":"The synergistic activity between Cry1Aa and Cry1C from Bacillus thuringiensis against Spodoptera exigua and Helicoverpa armigera","volume":"40","author":"Xue","year":"2005","journal-title":"Lett Appl Microbiol"},{"key":"10.1111\/lam.12219-BIB0038|lam12219-cit-0038","first-page":"1033","article-title":"A novel negative regulatory factor for nematicidal Cry protein gene expression in Bacillus thuringiensis","volume":"18","author":"Yu","year":"2008","journal-title":"J Microbiol Biotechnol"},{"key":"10.1111\/lam.12219-BIB0039|lam12219-cit-0039","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s00284-011-0070-7","article-title":"Co-expression and synergism analysis of Vip3Aa29 and Cyt2Aa3 insecticidal proteins from Bacillus thuringiens","volume":"64","author":"Yu","year":"2012","journal-title":"Curr Microbiol"},{"key":"10.1111\/lam.12219-BIB0040|lam12219-cit-0040","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1472-765X.2005.01817.x","article-title":"Vegetative insecticidal protein enhancing the toxicity of Bacillus thuringiensis subsp. kurstaki against Spodoptera exigua","volume":"42","author":"Zhu","year":"2005","journal-title":"Lett Appl Microbiol"}],"container-title":["Letters in Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Flam.12219","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Flam.12219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/lam.12219\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T15:01:32Z","timestamp":1676386892000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lambio\/article\/58\/6\/511\/6699642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,18]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"URL":"https:\/\/doi.org\/10.1111\/lam.12219","archive":["Portico"],"relation":{},"ISSN":["0266-8254"],"issn-type":[{"value":"0266-8254","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2,18]]}}}