{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:30:41Z","timestamp":1782491441001,"version":"3.54.5"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Programa Operacional, Fatores de competitividade \u2013 COMPETE"},{"DOI":"10.13039\/501100001871","name":"FCT \u2013 Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["FCT PTDC\/SAU-MIC\/119069\/2010"],"award-info":[{"award-number":["FCT PTDC\/SAU-MIC\/119069\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT \u2013 Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["RECI\/EBB-EBI\/0179\/2012"],"award-info":[{"award-number":["RECI\/EBB-EBI\/0179\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT \u2013 Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PEst-OE\/EQB\/LA0023\/2013"],"award-info":[{"award-number":["PEst-OE\/EQB\/LA0023\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT \u2013 Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/93078\/2013"],"award-info":[{"award-number":["SFRH\/BD\/93078\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa Operacional Regional do Norte"},{"name":"QREN"},{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Candida species are responsible for recurrent human infections, mostly in immunocompromised patients, due to their high vulnerability. Candida glabrata has a major role in systemic candidiasis and Amphotericin B (AmB), a polyene only used in hospitals, is frequently used to treat this disease. Lately, however, clinical evidences of Candida recurrent infections during these treatments are being described, probably due to biofilm (re)formation during this therapy. Thus, this work aims at inferring if C. glabrata biofilms are still being formed during AmB treatment. For that, C. glabrata biofilms were formed in the presence of AmB and analysed by dry weight. Matrix composition was analysed quantifying carbohydrates and, specifically, \u03b2-1,3 glucans. Results demonstrated that, although in a lesser extent, C. glabrata is able to develop biofilms in the presence of AmB, with a thick extracellular matrix, with an increase on carbohydrates, especially \u03b2-1,3 glucans. Therefore, it is confirmed that complex biofilms of C. glabrata can be formed during an AmB treatment.<\/jats:p>\n               <jats:sec>\n                  <jats:title>Significance and Impact of the Study<\/jats:title>\n                  <jats:p>This study shows new insights regarding recurrent candidiasis. The authors demonstrated that Amphotericin B did not totally prevent the development of biofilms during Candida glabrata's infection treatment and that the change in the biofilm matrices may have a high responsibility for the fail in the treatment of systemic candidiasis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/lam.12600","type":"journal-article","created":{"date-parts":[[2016,6,4]],"date-time":"2016-06-04T05:42:28Z","timestamp":1465018948000},"page":"77-81","source":"Crossref","is-referenced-by-count":21,"title":["<i>Candida glabrata's<\/i> recurrent infections: biofilm formation during Amphotericin B treatment"],"prefix":"10.1093","volume":"63","author":[{"given":"C.F.","family":"Rodrigues","sequence":"first","affiliation":[{"name":"CEB, Centre of Biological Engineering LIBRO \u2013 Laborat\u00f3rio de Investiga\u00e7\u00e3o em Biofilmes Ros\u00e1rio Oliveira University of Minho Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Silva","sequence":"additional","affiliation":[{"name":"CEB, Centre of Biological Engineering LIBRO \u2013 Laborat\u00f3rio de Investiga\u00e7\u00e3o em Biofilmes Ros\u00e1rio Oliveira University of Minho Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Azeredo","sequence":"additional","affiliation":[{"name":"CEB, Centre of Biological Engineering LIBRO \u2013 Laborat\u00f3rio de Investiga\u00e7\u00e3o em Biofilmes Ros\u00e1rio Oliveira University of Minho Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Henriques","sequence":"additional","affiliation":[{"name":"CEB, Centre of Biological Engineering LIBRO \u2013 Laborat\u00f3rio de Investiga\u00e7\u00e3o em Biofilmes Ros\u00e1rio Oliveira University of Minho Braga 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