{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:06:24Z","timestamp":1767859584930,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB721006"],"award-info":[{"award-number":["2012CB721006"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21276081"],"award-info":[{"award-number":["21276081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lett Appl Microbiol"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1111\/lam.12635","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T07:36:41Z","timestamp":1471592201000},"page":"384-390","source":"Crossref","is-referenced-by-count":17,"title":["Enhanced production of avermectin by deletion of type III polyketide synthases biosynthetic cluster<i>rpp<\/i>in<i>Streptomyces avermitilis<\/i>"],"prefix":"10.1093","volume":"63","author":[{"given":"L.","family":"Meng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering; East China University of Science and Technology; Shanghai China"},{"name":"Key Laboratory of Synthetic Biology; CAS Center for Excellence in Molecular Plant Sciences; Institute of Plant Physiology and Ecology; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Medical Instrument and Food Engineering; University of Shanghai for Science and Technology; Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Chu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering; East China University of Science and Technology; Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering; East China University of Science and Technology; Shanghai China"},{"name":"Key Laboratory of Synthetic Biology; CAS Center for Excellence in Molecular Plant Sciences; Institute of Plant Physiology and Ecology; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,10,17]]},"reference":[{"key":"10.1111\/lam.12635-BIB0001|lam12635-cit-0001","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2958.2010.07274.x","article-title":"FasR, a novel class of transcriptional regulator, governs the activation of fatty acid biosynthesis genes in Streptomyces coelicolor","volume":"78","author":"Arabolaza","year":"2010","journal-title":"Mol Microbiol"},{"key":"10.1111\/lam.12635-BIB0002|lam12635-cit-0002","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1128\/AAC.15.3.361","article-title":"Avermectins, new family of potent anthelmintic agents: producing organism and fermentation","volume":"15","author":"Burg","year":"1979","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/lam.12635-BIB0003|lam12635-cit-0003","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin Chem"},{"key":"10.1111\/lam.12635-BIB0004|lam12635-cit-0004","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1128\/AAC.15.3.372","article-title":"Avermectins, new family of potent anthelmintic agents: efficacy of the B1a component","volume":"15","author":"Egerton","year":"1979","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/lam.12635-BIB0005|lam12635-cit-0005","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/23748","article-title":"A new pathway for polyketide synthesis in microorganisms","volume":"400","author":"Funa","year":"1999","journal-title":"Nature"},{"key":"10.1111\/lam.12635-BIB0006|lam12635-cit-0006","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1021\/cr960023p","article-title":"Avermectin biosynthesis","volume":"97","author":"Ikeda","year":"1997","journal-title":"Chem Rev"},{"key":"10.1111\/lam.12635-BIB0007|lam12635-cit-0007","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10295-013-1327-x","article-title":"Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters","volume":"41","author":"Ikeda","year":"2014","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1111\/lam.12635-BIB0008|lam12635-cit-0008","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/B978-0-12-394290-6.00017-3","article-title":"Type III polyketide synthases in microorganisms","volume":"515","author":"Katsuyama","year":"2012","journal-title":"Methods Enzymol"},{"key":"10.1111\/lam.12635-BIB0009|lam12635-cit-0009","first-page":"249","volume-title":"Practical Streptomyces Genetics","author":"Kieser","year":"2000"},{"key":"10.1111\/lam.12635-BIB0010|lam12635-cit-0010","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2958.2009.06968.x","article-title":"PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis in Streptomyces cacaoi","volume":"75","author":"Li","year":"2010","journal-title":"Mol Microbiol"},{"key":"10.1111\/lam.12635-BIB0011|lam12635-cit-0011","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.biortech.2010.09.102","article-title":"Enhanced production of ansamitocin P-3 by addition of isobutanol in fermentation of Actinosynnema pretiosum","volume":"102","author":"Lin","year":"2011","journal-title":"Bioresour Technol"},{"key":"10.1111\/lam.12635-BIB0012|lam12635-cit-0012","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1128\/JB.00716-13","article-title":"Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis","volume":"195","author":"Liu","year":"2013","journal-title":"J\u00a0Bacteriol"},{"issue":"Pt 11","key":"10.1111\/lam.12635-BIB0013|lam12635-cit-0013","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1099\/00221287-145-11-3109","article-title":"Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2)","volume":"145","author":"Rodriguez","year":"1999","journal-title":"Microbiology"},{"key":"10.1111\/lam.12635-BIB0014|lam12635-cit-0014","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1128\/AEM.67.9.4166-4176.2001","article-title":"Role of an essential acyl coenzyme A carboxylase in the primary and secondary metabolism of Streptomyces coelicolor A3(2)","volume":"67","author":"Rodriguez","year":"2001","journal-title":"Appl Environ Microbiol"},{"key":"10.1111\/lam.12635-BIB0015|lam12635-cit-0015","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000356189","article-title":"The state of RT-quantitative PCR: firsthand observations of implementation of minimum information for the publication of quantitative real-time PCR experiments\u00a0(MIQE)","volume":"24","author":"Taylor","year":"2014","journal-title":"J Mol Microbiol Biotechnol"},{"key":"10.1111\/lam.12635-BIB0016|lam12635-cit-0016","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s10529-006-9012-z","article-title":"Enhancement and selective production of oligomycin through inactivation of avermectin's starter unit in Streptomyces avermitilis","volume":"28","author":"Wei","year":"2006","journal-title":"Biotechnol Lett"},{"key":"10.1111\/lam.12635-BIB0017|lam12635-cit-0017","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1007\/s13277-013-1357-z","article-title":"XRCC3 Thr241Met polymorphism and ovarian cancer risk: a meta-analysis","volume":"35","author":"Yan","year":"2014","journal-title":"Tumour Biol"},{"key":"10.1111\/lam.12635-BIB0018|lam12635-cit-0018","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00253-003-1491-4","article-title":"Avermectin: biochemical and molecular basis of its biosynthesis and regulation","volume":"63","author":"Yoon","year":"2004","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1111\/lam.12635-BIB0019|lam12635-cit-0019","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1128\/JB.178.2.490-495.1996","article-title":"Cloning and characterization of a gene (msdA) encoding methylmalonic acid semialdehyde dehydrogenase from Streptomyces coelicolor","volume":"178","author":"Zhang","year":"1996","journal-title":"J Bacteriol"},{"key":"10.1111\/lam.12635-BIB0020|lam12635-cit-0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1574-6968.2012.02609.x","article-title":"Sequential deletion of all the polyketide synthase and nonribosomal peptide synthetase biosynthetic gene clusters and a 900-kb subtelomeric sequence of the linear chromosome of Streptomyces coelicolor","volume":"333","author":"Zhou","year":"2012","journal-title":"FEMS Microbiol Lett"}],"container-title":["Letters in Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Flam.12635","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Flam.12635","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/lam.12635\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T22:43:25Z","timestamp":1718750605000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lambio\/article\/63\/5\/384\/6699115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,17]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"URL":"https:\/\/doi.org\/10.1111\/lam.12635","archive":["Portico"],"relation":{},"ISSN":["0266-8254"],"issn-type":[{"value":"0266-8254","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10,17]]}}}