{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:46:48Z","timestamp":1780498008049,"version":"3.54.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to evaluate the performance of hydrogen peroxide vapour (HPV) to inactivate the chimpanzee adenovirus AZD1222 vaccine strain used in the production of recombinant COVID-19 vaccine for application in cleaning validation in pharmaceutical industries production areas. Two matrixes were tested: formulated recombinant COVID-19 vaccine (FCV) and active pharmaceutical ingredient (API). The samples were dried on stainless steel and exposed to HPV in an isolator. One biological indicator with population &amp;gt;106 \u00a0Geobacillus stearothermophilus spores was used to validate the HPV decontamination cycle as standard. HPV exposure resulted in complete virus inactivation in FVC (\u22655\u00b703 log10) and API (\u22656\u00b740 log10), showing HPV efficacy for reducing chimpanzee adenovirus AZD1222 vaccine strain. However, the optimum concentration and contact time will vary depending on the type of application. Future decontamination studies scaling up the process to the recombinant COVID-19 vaccine manufacturing areas are necessary to evaluate if the HPV will have the same or better virucidal effectivity in each specific production area. In conclusion, HPV showed efficacy for reducing AZD1222 chimpanzee adenovirus strain and can be a good choice for pharmaceutical industries facilities disinfection during recombinant COVID-19 vaccine production.<\/jats:p>","DOI":"10.1111\/lam.13635","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T06:34:56Z","timestamp":1639809296000},"page":"536-542","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of hydrogen peroxide efficacy against AZD1222 chimpanzee adenovirus strain in the recombinant COVID-19 vaccine for application in cleaning validation in a pharmaceutical manufacturing industry"],"prefix":"10.1093","volume":"74","author":[{"given":"A.C.F.B.","family":"Ajorio","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology Control Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.P.","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.P.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.A.","family":"Diniz","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.V.","family":"Mattoso","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.B.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.M.","family":"D`Aiuto","sequence":"additional","affiliation":[{"name":"Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1121-7312","authenticated-orcid":false,"given":"M.L.L.","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,1]]},"reference":[{"key":"2023011712224197500_lam13635-bib-0001","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.vaccine.2015.12.041","article-title":"Inactivation of rabies virus by hydrogen peroxide","volume":"34","author":"Abd-Elghaffar","year":"2016","journal-title":"Vaccine"},{"key":"2023011712224197500_lam13635-bib-0002","article-title":"Evaluation of hydrogen peroxide virucidal efficacy against yellow fever virus 17DD vaccine strain for application in a vaccine manufacturing industry","volume":"204","author":"Ajorio","year":"2021","journal-title":"J Pharm Biomed Anal"},{"key":"2023011712224197500_lam13635-bib-0003","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jhin.2017.09.011","article-title":"Test parameters for efficacy evaluations of aerial hydrogen peroxide decontamination systems","volume":"98","author":"Ali","year":"2018","journal-title":"J Hosp Infect"},{"key":"2023011712224197500_lam13635-bib-0004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0243126","article-title":"COVID-19 hospitalizations in Brazil's Unified Health System (SUS)","volume":"15","author":"de Andrade","year":"2020","journal-title":"PLoS One"},{"key":"2023011712224197500_lam13635-bib-0005","volume-title":"Farmacopeia Brasileira. 6\u00aa edi\u00e7\u00e3o - produtos biol\u00f3gicos","author":"Brasil. 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