{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:00:28Z","timestamp":1785319228392,"version":"3.55.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Yunnan Provincial Department of Science and Technology and Yunnan University of Traditional Chinese Medicine applied basic Research Joint Special Project","award":["2017FF116-028"],"award-info":[{"award-number":["2017FF116-028"]}]},{"name":"The Joint Special Fund of Science and Technology Department of Yunnan Province-Yunnan University of Chinese Medicine","award":["2017FF117-003"],"award-info":[{"award-number":["2017FF117-003"]}]},{"name":"the Foundation of Scientific Research Project of the National Natural Science Foundation of China","award":["81660737"],"award-info":[{"award-number":["81660737"]}]},{"name":"The Joint Special Fund of Yunnan Provincial Science and Technology Department","award":["2017FF117-025"],"award-info":[{"award-number":["2017FF117-025"]}]},{"name":"Scientific Research Foundation of Education Department of Yunnan Province","award":["2014Y238"],"award-info":[{"award-number":["2014Y238"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vulvovaginal candidiasis (VVC) is an infectious disease caused mainly by Candida albicans. Kangfuxin (KFX) is a traditional Chinese medicine preparation made from Periplaneta americana extracts, which promotes wound healing and enhances body immunity and also acts as an antifungal agent. Here, we evaluated the effect of KFX in the treatment of VVC in vitro and in vivo. The minimum inhibitory concentration (MIC50) of KFX against C. albicans ranged from 7\u00b765 to 20\u00b757%. In addition, KFX was more efficient than fluconazole (FLC) in inhibiting the drug-resistant C. albicans, and the effect was more intense after 8 h. The KFX treatment also exhibited good activity in vivo. It restored the body weight and reduced the vulvovaginal symptoms in mice induced with VVC. It downregulated the expression of the hyphae-related gene, HWP1, thus inhibiting the growth and development of C. albicans hyphae. It also increased the number of neutrophils and promoted the secretion of interleukin-17A (IL-17A); however, the levels of interleukin-8 (IL-8) and interleukin-1\u03b2 (IL-1\u03b2) decreased in mice with VVC. We deduce that KFX effectively treats vaginal candidiasis in two ways: by inhibiting the growth and development of mycelia to reduce colonization of C. albicans and by promoting the secretion and release of IL-17A and neutrophils in high numbers to fight C. albicans infection. This study provides a theoretical basis for the use of KFX for the clinical treatment of VVC.<\/jats:p>","DOI":"10.1111\/lam.13641","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T19:27:01Z","timestamp":1640633221000},"page":"564-576","source":"Crossref","is-referenced-by-count":9,"title":["The liquid Kangfuxin (KFX) has efficient antifungal activity and can be used in the treatment of vulvovaginal candidiasis in mice"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3014-012X","authenticated-orcid":false,"given":"J.","family":"Ma","sequence":"first","affiliation":[{"name":"College of Pharmacy Dali University Dali China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-C.","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chinese Materia Medica Yunnan University of Chinese Medicine Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-Q.","family":"Su","sequence":"additional","affiliation":[{"name":"College of Chinese Materia Medica Yunnan University of Chinese Medicine Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.-M.","family":"Qin","sequence":"additional","affiliation":[{"name":"College of Chinese Materia Medica Yunnan University of Chinese Medicine Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College Yunnan University of Chinese Medicine Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chinese Materia Medica Yunnan University of Chinese Medicine Kunming 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