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This study assessed the antifungal effects of nanoparticles (NPs) on the standard strains of Candida albicans and Candida glabrata and determined the expression genes, including ERG3, ERG11 and FKS1. Selenium nanoparticles (Se-NPs) were biosynthesized with a standard strain of C. albicans and approved by several methods including, ultraviolet-visible spectrophotometer, X-ray diffraction technique, Fourier-transform infrared analysis, field-emission scanning electron microscopy and EDX diagram. The antifungal susceptibility testing performed the minimum inhibitory concentrations (MICs) using the CLSI M27-A3 and M27-S4 broth microdilution method. The expression of the desired genes was examined by the real-time PCR assay between untreated and treated by antifungal drugs and Se-NPs. The MICs of itraconazole, amphotericin B and anidulafungin against C. albicans and C. glabrata were 64, 16 and 4 \u00b5g ml\u22121. In comparison, reduced the MIC values for samples treated with Se-NPs to 1 and 0\u00b75 \u00b5g ml\u22121. The results obtained from real-time PCR and analysis of the \u2206\u2206Cq values showed that the expression of ERG3, ERG11 and FKS1 genes was significantly down-regulated in Se-NPs concentrations (P &amp;lt; 0\u00b705). This study's evidence implies biosafety Se-NPs have favourable effects on the reducing expression of ERG3, ERG11 and FKS1 antifungal resistance genes in C. albicans and C. glabrata.<\/jats:p>","DOI":"10.1111\/lam.13667","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T14:20:14Z","timestamp":1644416414000},"page":"809-819","source":"Crossref","is-referenced-by-count":40,"title":["Green synthesis of selenium nanoparticles and evaluate their effect on the expression of ERG3, ERG11 and FKS1 antifungal resistance genes in Candida albicans and Candida glabrata"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-3170","authenticated-orcid":false,"given":"M.","family":"Hosseini Bafghi","sequence":"first","affiliation":[{"name":"Department of Laboratory Sciences Faculty of Paramedical Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Department of Microbiology Faculty of Science Qom Branch Islamic Azad University Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1449-4668","authenticated-orcid":false,"given":"H.","family":"Zarrinfar","sequence":"additional","affiliation":[{"name":"Allergy Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-7242","authenticated-orcid":false,"given":"M.","family":"Darroudi","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3108-5655","authenticated-orcid":false,"given":"M.","family":"Zargar","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Science Qom Branch Islamic Azad University Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-1416","authenticated-orcid":false,"given":"R.","family":"Nazari","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Science Qom Branch Islamic Azad University Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,1]]},"reference":[{"key":"2023011712225724500_lam13667-bib-0001","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12668-017-0413-3","article-title":"Recent advances in green synthesis of silver nanoparticles and their applications: about future directions. 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