{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:21:27Z","timestamp":1792516887020,"version":"4.5.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1804136"],"award-info":[{"award-number":["U1804136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this work, the antibacterial activity and mechanism of chloroform fraction obtained from aqueous extract of mugwort leaves against Staphylococcus aureus were investigated. The extract showed obvious antibacterial activity against S. aureus which the minimum inhibitory concentration and minimum bactericidal concentration were determined to be 3\u00b70 and 6\u00b70 mg ml\u22121 respectively. The mechanism study suggested that the extract could destroy the integrity of the S. aureus cell walls and increase the permeability of cell membrane in a certain concentration, but it could not kill S. aureus in a short time. Instead, the extract could make bacteria in a state of apoptosis for a long time, interfere with the normal physiological metabolism of bacteria, and eventually make bacteria die, which was confirm by scanning electronic microscope.<\/jats:p>","DOI":"10.1111\/lam.13684","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T17:46:19Z","timestamp":1646156779000},"page":"893-900","source":"Crossref","is-referenced-by-count":34,"title":["Antibacterial activity and mechanism of chloroform fraction from aqueous extract of mugwort leaves (Artemisia argyi L.) against Staphylococcus aureus"],"prefix":"10.1093","volume":"74","author":[{"given":"J.-J.","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University Zhengzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-B.","family":"Qu","sequence":"additional","affiliation":[{"name":"Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications College of Chemistry Zhengzhou University Zhengzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-F.","family":"Bi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University Zhengzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-X.","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University Zhengzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Yang","sequence":"additional","affiliation":[{"name":"Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications College of Chemistry Zhengzhou University Zhengzhou PR 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